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Young-Mo Kim

Institution
Pacific Northwest National Laboratory
ORCID
ORCID logo 0000-0002-8972-7593

Projects

Agile Biofoundry FY24-25

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Nathalie Munoz Munoz
This proposed EMSL Staff time proposal assists the DOE-EERE-BETO supported PNNL project: FY24-25 seven-national laboratory Agile BioFoundry (https://agilebiofoundry.org/). PNNL’s effort for this…

Multi-Scale Multi-Modality High Resolution Mapping of the Adult Human Lung

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Christopher Anderton
The Human Biomolecular Atlas Program (HuBMAP) is entering the production phase, with an emphasis on progressive, high sensitivity and specificity assays, prioritizing spatial biomolecular analysis…

EPICON: Epigenetic Control of Drought Acclimation in Sorghum

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Christer Jansson
Genetic manipulation of crops to increase the presence or intensity of desirable traits has been critical to increasing agricultural productivity. These changes have primarily involved modification…

Yarrowia lipolytica for biotechnology and synthetic biology

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Scott Baker
The team at PNNL is using a combination of flow cytometry, microscopy and lipidomics to establish baseline cell biological and metabolite data on lipid production by the W29 strain of Yarrowia…

Agile BioFoundry

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Scott Baker
This proposed EMSL Resource Owner project, is a sub-project supporting two DOE-EERE-BETO supported PNNL projects: FY16-17 four-national laboratory “Agile BioFoundry” (ABF) seed project and a larger…

Wood decomposition by brown rot fungi

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Young-Mo Kim
Fungi dominate the biological decomposition of wood and other lignocellulosic plant tissues in nature through a range of pathways for unlocking the sugars embedded in lignin, offering a proven model…

Undiagnosed Diseases Network Metabolomics Core

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
A state of the art metabolomics core will be a vital part of the Undiagnosed Diseases Network (UDN). However, in order for the UDN to realize it’s the full potential it is essential that the…

Dissection and Deciphering of the Soil Microbiome

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Janet Jansson
This proposal aims to address key gaps in our knowledge about the composition and functional roles of the tens of thousands of microbial species in soil. Although these microorganisms carry out…

Yarrowia lipolytica for biotechnology and synthetic biology

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Erin Bredeweg
The team at PNNL is using a combination of flow cytometry, microscopy and lipidomics/metabolomics to establish baseline cell biological and metabolite data on DNA agility in eukaryotic organisms, and…

Deciphering Microbial Communication Through Metabolites

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
This project will establish a Metabolomics Center at PNNL that will develop the advanced measurement capabilities necessary to define the metabolic processes of microbiomes and determine how these…

Metabolomic and Lipidomic Analysis of Subjects with Galactosemia

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Jennifer Kyle
Galactosemia is a rare, genetic, metabolic disease affecting how the body processes galactose. Classical galactosemia, affecting 1 in 30,000 to 60,000 newborns, is a severe form of the disease…

Undiagnosed Diseases Network Metabolomics Core

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
A state of the art metabolomics core will be a vital part of the Undiagnosed Diseases Network (UDN). However, in order for the UDN to realize it’s the full potential it is essential that the…

Predictive Modeling of Viral Pathogenesis

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joshua Adkins
The interactions between a host and a pathogen are complex, representing a molecular interplay that results in either health or disease as an outcome. Understanding the nuances of these interactions…

Establishment of a Robust Method for Soil Metabolomics Analysis

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Vanessa Bailey
Project type
Limited Scope
The objective of this work is to adapt current evolving protocols for metabolomics analyses to soil samples. As chemical perturbations are primarily detected on a molecular level, the metabolome will…

Agile BioFoundry

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Jon Magnuson
This proposed EMSL Resource Owner project, is a sub-project supporting DOE-EERE-BETO supported PNNL-national laboratory Agile BioFoundry (ABF) project. PNNL’s effort for this project, which includes…

Agile BioFoundry

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Jon Magnuson
This proposed EMSL Resource Owner project, is a sub-project supporting two DOE-EERE-BETO supported PNNL projects: FY16-17 four-national laboratory “Agile BioFoundry” (ABF) seed project and a larger…

Predictive Modeling of Viral Pathogenesis

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joshua Adkins
The interactions between a host and a pathogen are complex, representing a molecular interplay that results in either health or disease as an outcome. Understanding the nuances of these interactions…

Centralized Metabolomics Molecular Reference Database

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Yuri Eberlim de Corilo
Reference databases, both in-silico and molecular standard-based, are vital components in all metabolomics data annotation workflows. However, these databases are often decentralized or have…

Multi-platform 'Omics Analysis to Determine TB Vaccine Correlates

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Jennifer Kyle
In recent years, mass spectrometry-based integrated multi-omics analyses have allowed for powerful interrogations of patient samples, and the identification of correlates of risk for tuberculosis…

GC-MS Analysis of Alkaline Cellulose Degradation Products

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
John Cort
Project type
Exploratory Research
Degradation of cellulose and other polysaccharides in alkaline conditions and at elevated temperatures yields mixtures of compounds containing carboxylic acid and/or alcohol functional groups. These…

Agile BioFoundry

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Kristin Burnum-Johnson
This proposed EMSL Resource Owner project, is a sub-project supporting two DOE-EERE-BETO supported PNNL projects: FY16-17 four-national laboratory “Agile BioFoundry” (ABF) seed project and a larger…