Zhangyang Xu

A streamlined platform for phosphoproteome mapping of human tissues

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Tujin Shi

Recent technological advances in genomics, transcriptomics, and proteomics allow for rapid generation of comprehensive 3D-human tissue maps for biomolecules DNAs, RNAs, and proteins at the single…

A scalable mass spectrometry platform for proteome mapping of brain tissues

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Tujin Shi

The brain is the most complex organ in the mammalian body. Bulk analysis obscures heterogeneity of cell types present even in the smallest brain regions. Multi-omics single-cell resolution 3D…

Targeted proteomics technology for accurate quantitative single-cell proteomics

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Tujin Shi

Multi-omics characterization of a broad spectrum of small subpopulations of cells between tumors and within individual tumors at the single-cell resolution is crucial to achieve understanding of a…

Collaborative research projects in the PNNL NIH P41 Biomedical Technology Research Center 'Proteomics research resource for integrative biology'

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Jon Jacobs

Collaborative research projects in the PNNL NIH P41 Biomedical Technology Research Center 'Proteomics research resource for integrative biology'

Structure and Chemistry at the Buried Solid/Aqueous Solution Interfaces with Advanced Surface Nonlinear Spectroscopy

Lead Institution

Fudan University

Principal Investigator

Hongfei Wang

Solid/aqueous solution interface are ubiquitous and important in energy and environmental research. We propose to investigate benchmark systems in the interface sciences to find novel applications of…

The Transformation of Tetrahedral to Octahedral Coordination in Anions of Interest in High-Level Tank Waste

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Jian-zhi Hu

Project type

Large-Scale EMSL Research

We propose to use nuclear magnetic resonance (NMR), Raman and Fourier transform-infrared (FT-IR) spectroscopy in combination with computational modeling to study the conversion of soluble tetrahedral…

Serum biomarkers for predicting type 1 diabetes

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Weijun Qian

Clinical type 1 diabetes (T1D) is preceded by an asymptomatic phase of the disease, which can be readily identified by serum islet autoantibodies(AAb). However, the T1D field is challenged by the…

Multimodal Chemical Imaging Across Scales to Visualize Metabolic Pathways in Live Plants and Microbial Systems

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Scott Lea

We will develop a novel spectral imaging platform (“BioImager”) that may be used to image and identify biomolecules involved in both microbial and plant metabolic processes through different chemical…

Pentosan Polysulfate Sodium Profiling with Ion Mobility Mass Spectrometry

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

John Cort

Pentosan polysulfate sodium, known as PPS, is the active pharmaceutical ingredient in the prescription drug Elmiron, and is indicated for interstitial cystitis, a painful bladder condition caused by…

Unraveling chemical speciation and interfacial dynamics in complex, heterogeneous
environments to efficiently process high-level radioactive wastes

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Jian-zhi Hu

We propose to use NMR in combination with computational modeling, to study the conversion of soluble tetrahedral aluminum (Al) species to octahedrally coordinated Al-bearing mineral precipitates…

Multimodal Chemical Imaging Across Scales to Visualize Metabolic Pathways in Live Plants and Microbial Systems

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Scott Lea

We will develop a novel spectral imaging platform (“BioImager”) that may be used to image and identify biomolecules involved in both microbial and plant metabolic processes through different chemical…

Projects