Comparative Protein Structure Modeling:
From Protein Sequence to High-accuracy Protein Structure
EMSL Project ID
13304
Abstract
We propose to implement a computational pipeline for high-accuracy protein structure prediction from protein sequence, and carry out testing and evaluation of this computational pipeline on proteins with low sequence identities (< 25%) with their native-like structural folds in the PDB database. This computational pipeline will consist of computational tools for (a) protein fold recognition, (b) sequence-structure alignment, (c) prediction of side-chains, and (d) structural refinement using molecular mechanics methods.
Project Details
Project type
Capability Research
Start Date
2005-03-01
End Date
2006-12-06
Status
Closed
Released Data Link
Team
Principal Investigator
Team Members