Grand Challenge in Membrane Biology
EMSL Project ID
14398
Abstract
In this grand challenge, we will use a systems approach to understand the network of genes and proteins that govern the structure and function of membranes and their components responsible for photosynthesis and nitrogen fixation in cyanobacteria (blue-green algae). A systems approach integrates all temporal information into a predictive, dynamic model to understand the function of a cell and the cellular membranes. These microorganisms make significant contributions to harvesting solar energy, planetary carbon sequestration, metal acquisition, and hydrogen production in marine and freshwater ecosystems. Cyanobacteria are also model microorganisms for studying the fixation of carbon dioxide through photosynthesis at the biomolecular level. The results of this Grand Challenge will provide the first comprehensive systems level understanding of how environmental conditions influence key carbon fixation processes at the gene-protein-organism level. Specific tasks associated with this grand challenge will be submitted individually.
Project Details
Project type
Grand Challenge
Start Date
2005-03-31
End Date
2011-04-03
Status
Closed
Released Data Link
Team
Principal Investigator
Team Members
Related Publications
Crystal structure of cce_0566 fromCyanothece 51142, a protein associated with nitrogen fixation in the DUF269 family
Buchko GW, and H Robinson. 2012. "Crystal structure of cce_0566 from Cyanothece 51142, a protein associated with nitrogen fixation in the DUF269 family." FEBS Letters 586(4):350-355. doi:10.1016/j.febslet.2012.01.037
Cloning, expression, crystallization and preliminary crystallographic analysis of a pentapeptide-repeat protein (Rfr23) from the bacteriumCyanothece 51142
Buchko GW, H Robinson, S Ni, HB Pakrasi, and MA Kennedy. 2006. "Cloning, expression, crystallization and preliminary crystallographic analysis of a pentapeptide-repeat protein (Rfr23) from bacterium Cyanothece 511421." Acta Crystallographica. Section F 62(12):1251-1254. doi:10.1107/S174430910604663X