Structure of Designer Proteins
EMSL Project ID
16722a
Abstract
Protein design is one of the great challenges of modern molecular biology, promising to provide entirely new biological activities together with an unprecedented understanding of protein structure and stability. Achieving atomic level resolution in the computational design of a protein structure remains a challenging problem despite much recent progress. Rigorous experimental tests are needed to improve protein design algorithms, yet studies of the structure and dynamics of computationally designed proteins remain very few. We are using NMR to study the structures and dynamics of several proteins designed in the Baker laboratory to fold into new structures, or that are designed to re-capitulate existing structures. These studies are providing needed information that is being used to identify limitations in the design algorithms and therefore to improve them.
Project Details
Project type
Capability Research
Start Date
2006-04-04
End Date
2006-11-21
Status
Closed
Released Data Link
Team
Principal Investigator
Team Members