High Throughput Proteomic & Metabolomic Early Biomarkers (PNNL Scope #47174, RD Smith's EIF project)
EMSL Project ID
17799
Abstract
Abstract
Proteomic and metabolomic applications of high throughput, quantitative measurements using the accurate mass and time (AMT) tag approach for discovering early biomarkers in blood plasma and nipple aspirate fluid for human breast cancer. ASSUMPTIONS: EIF expects us to conduct fundamental research to further our knowledge in areas of importance to their mission, and to disseminate this knowledge through publications in peer-reviewed journals and presentations of research at scientific meetings.
Project Details
Start Date
2006-02-02
End Date
2009-02-08
Status
Closed
Released Data Link
Team
Principal Investigator
Team Members
Related Publications
Kelly, RT, JS Page, R Zhao, W-J Qian, HM Mottaz, K Tang, and RD Smith. "Capillary-Based Multi Nanoelectrospray Emitters: Improvements in Ion Transmission Efficiency and Implementation with Capillary Reversed-Phase LC-ESI-MS." 2008. Analytical Chemistry 80(1):143-149. doi:10.1021/ac701647s.
Qian, W-J, DT Kaleta, BO Petritis, H Jiang, T Liu, X Zhang, HM Mottaz, SM Varnum, DG Camp II, L Huang, X Fang, W-W Zhang, and RD Smith. 2008. "Enhanced Detection of Low Abundance Human Plasma Proteins Using a Tandem IgY12-SuperMix Immunoaffinity Separation Strategy." Molecular & Cellular Proteomics 7:1963-1973.
Qian WJ, JM Jacobs, T Liu, DG Camp, and RD Smith. 2006. "Advances and challenges in liquid chromatography-mass spectrometry-based proteomics profiling for clinical applications." Molelcular and Cellular Proteomics 5(10):1727-1744.