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Structural Genomics of Eukaryotic Model Organisms


EMSL Project ID
2450

Abstract

The primary goal of our pilot project is to develop integrated technologies for high-throughput (htp) protein production and 3D structure determination. These will form key components of the scientific infrastructure required for the next stage of genome research beyond DNA sequencing. Our NESG Consortium has the particular focus of evaluating the role of protein NMR spectroscopy in future Structural Proteomics Centers to be funded by NIH. Our targets include members of large protein families for which no 3D structural information is available. We prioritize protein families with representatives in human and higher eukaryotic genomes because of the important role of these proteins in human health and model organism biology.. We rely heavily on distributed NMR data collection facilities, particularly those at Pacific Northwest National Laboratories.

Project Details

Project type
Capability Research
Start Date
2002-04-01
End Date
2002-11-18
Status
Closed

Team

Principal Investigator

Gaetano Montelione
Institution
Rutgers University

Related Publications

Yin C, JM Aramini, LC Ma, JR Cort, GVT Swapna, RM Krug, and G Montelione. 2011. "Backbone and Ile-?1, Leu, Val Methyl 1H, 13C and 15N NMR chemical shift assignments for human interferon-stimulated gene 15 protein." Biomolecular NMR Assignments 5(2):215-219. doi:10.1007/s12104-011-9303-8