Nanoparticles-Based Biosensors for Detection of Environmental Biomarkers
EMSL Project ID
24822
Abstract
Human exposure to toxic chemical agents (i.e. pesticides, nerve agents) and infectious agents, such as pathogens, may have some immune response, which is composed of both cellular and acellular components. Protein biomarkers are biomolecular signatures that display a unique pattern of molecular change in an organism, such as a set of expressed proteins, and that identify an exposure or response to a specific environmental stressor. Biological pathways that characterize organism response to environmental or biological agent exposures will be identified under the Environmental Biomarkers Initiative (EBI) at PNNL and 3 NIH funded projects. Moving this information to application will require methods of detection (i.e., biosensors) for biomarkers or biosignature patterns which are under discovery in several ongoing EBI projects and NIH funded projects (PI, Yuehe Lin). The EBI leadership has chosen to create this parallel path for sensor development in an effort to improve the Laboratorys ability to characterize and compare EBI-relevant detection methods. The major leap forward that has to occur is to also demonstrate that the new bioassays or devices will be more portable, sensitive, selective and real time than methods requiring large fluorescent microarray readers or flow cytometric equipment.
Project Details
Project type
Large-Scale EMSL Research
Start Date
2007-06-08
End Date
2010-09-30
Status
Closed
Released Data Link
Team
Principal Investigator
Team Members
Related Publications
Nanotechnology-based electrochemical sensors for biomonitoring chemical exposures
Barry RC, Y Lin, J Wang, G Liu, and C Timchalk. 2009. "Nanotechnology-Based Electrochemical Sensors for Biomonitoring Chemical Exposures ." Journal of Exposure Science and Environmental Epidemiology 19:1-18. doi:10.1038/jes.2008.71