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Fundamental Studies on Biomolecule Ions Desorbed from Open-Air Surfaces


EMSL Project ID
24993

Abstract

The mechanisms by which biologically-relevant molecules can be transformed into gas-phase ions is an area of active fundamental research in mass spectrometry (MS), which is relevant to a broad range of other scientific disciplines supported by the DOE Office of Science such as materials science, imaging, and spectroscopy. The proposed research will specifically focus on understanding the properties of protein, peptides and small drug molecule ions formed by recently-reported direct ionization techniques such as desorption electrospray ionization (DESI) and direct analysis in real time (DART) in combination with ultrahigh resolution mass spectrometry and surface ion activation techniques. These studies promise not only to shed more light on the fundamental processes involved in DESI and DART, but also to serve as the first stepping stone to develop new enabling technologies for environmental and biomedical proteomics and metabonomics. Our recent studies on DESI and DART, together with our previous collaboration, provide solid support for this work.

Project Details

Project type
Large-Scale EMSL Research
Start Date
2007-06-01
End Date
2009-09-30
Status
Closed

Team

Principal Investigator

Facundo Fernandez
Institution
Georgia Institute of Technology

Team Members

Leonard Nyadong
Institution
Georgia Institute of Technology

Zhibo Yang
Institution
University of Colorado at Boulder

Omar Hadjar
Institution
O.I. Analytical