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Single Molecule Studies of Multi-Chromophoric Foldamers


EMSL Project ID
27394

Abstract

Folding is a strategy ubiquitously used by nature to accomplish remarkable functions such as molecular recognition and enzymatic chemical catalysis. Since we are unable to design synthetic polymers that can fold and reproduce marvelous functions of nature, it is imperative that we further our understanding about the fundamental principles underpinning folding. In this project, we will focus on the origin of folding and folded structures that are stable at high or low temperatures. Specifically, we will systematically investigate the relationship between ?-stacked molecular structures and folding behaviors using single molecule fluorescence spectroscopy on foldable polymers or foldamers. Single molecule spectroscopic data at millisecond time scale will offer insightful information about folding and unfolding pathways of multi-chromophoric foldamers.

Project Details

Project type
Exploratory Research
Start Date
2007-08-31
End Date
2008-08-31
Status
Closed

Team

Principal Investigator

Alexander Li
Institution
Washington State University

Team Members

Dehong Hu
Institution
Environmental Molecular Sciences Laboratory

Related Publications

Hu D, Z Tian, W Wu, W Wan, and AD Li. 2008. "Photoswitchable Nanoparticles Enable High-Resolution Cell Imaging: PULSAR Microscopy." Journal of the American Chemical Society 130(46):15279-15281. doi:10.1021/ja805948u