Single Molecule Studies of Multi-Chromophoric Foldamers
EMSL Project ID
27394
Abstract
Folding is a strategy ubiquitously used by nature to accomplish remarkable functions such as molecular recognition and enzymatic chemical catalysis. Since we are unable to design synthetic polymers that can fold and reproduce marvelous functions of nature, it is imperative that we further our understanding about the fundamental principles underpinning folding. In this project, we will focus on the origin of folding and folded structures that are stable at high or low temperatures. Specifically, we will systematically investigate the relationship between ?-stacked molecular structures and folding behaviors using single molecule fluorescence spectroscopy on foldable polymers or foldamers. Single molecule spectroscopic data at millisecond time scale will offer insightful information about folding and unfolding pathways of multi-chromophoric foldamers.
Project Details
Project type
Exploratory Research
Start Date
2007-08-31
End Date
2008-08-31
Status
Closed
Released Data Link
Team
Principal Investigator
Team Members
Related Publications
Hu D, Z Tian, W Wu, W Wan, and AD Li. 2008. "Photoswitchable Nanoparticles Enable High-Resolution Cell Imaging: PULSAR Microscopy." Journal of the American Chemical Society 130(46):15279-15281. doi:10.1021/ja805948u