Discovery of Biomarkers Related to COPD
EMSL Project ID
30796
Abstract
Chronic Obstructive Pulmonary Disease (COPD) is a slowly progressive disease of the airways that is characterized by a gradual loss of lung function. COPD is a major cause of death and illness throughout the world, and is the fourth leading cause of death in the United States. The objective of this study is to identify putative biomarkers that may be predictive for, or correlate with, progression of COPD. Ultimately, and after extensive validation, the biomarkers may be useful for diagnosis and the determination of molecular targets and pathways. An initial step (Phase I of project) to accomplish this objective is the analysis of normal lung tissue by gel-free 2-D capillary liquid chromatography (LC)-MS/MS to establish a human lung tissue PMT database. Additional work in Phase 2 of the project will analyze lung samples from normal controls and patients with COPD. Project Details
Start Date
2008-06-30
End Date
2011-07-03
Status
Closed
Released Data Link
Team
Principal Investigator
Team Members
Related Publications
Webb-Robertson BJM, LA McCue, KM Waters, MM Matzke, JM Jacobs, TO Metz, SM Varnum, and JG Pounds. 2010. "Combined Statistical Analyses of Peptide Intensities and Peptide Occurrences Improves Identification of Significant Peptides from MS-based Proteomics Data." Journal of Proteome Research 9(11):5748-5756.