Structural Proteomics: annotating the genome using 3D structure
EMSL Project ID
3333a
Abstract
We are applying for NMR spectrometer time at EMSL as a continuation of our structural ^Mproteomics. Structural proteomics is based on the premise that a protein's biochemical function is ^M
often dictated by its 3 dimensional shape. Genome sequence of several organisms have shown that ^M
a large percentage of the genome encode for proteins which has no sequence homology to ^M
proteins of known function (currently refered to as hypothetical proteins). We hope the ^M
structures of these hypothetical proteins would provide some clues as to their function which can ^M
then be verified by other biochemical means. To date, our collaboration with Dr. Kennedy's ^M
laboratory had successfully solved 14 structures, 6 of which we were able to deduce the protein's ^M
function. Since our last applications for NMR spectrometer time last February, we have sent 3 ^M
additional samples for data acquisition.
Project Details
Project type
Capability Research
Start Date
2004-10-01
End Date
2005-09-30
Status
Closed
Released Data Link
Team
Principal Investigator
Team Members