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Structural Genomics of Eukaryotic Model Organisms


EMSL Project ID
3339

Abstract

ABSTRACT
The Northeast Structural Genomics Consortium is a NIH-funded pilot
project aimed at evaluating the feasibility, costs, economies of scale, and
value of structural proteomics. The primary goal of our pilot project is to
develop integrated technologies for high-throughput (htp) protein production
and 3D structure determination. Our NESG Consortium has the particular focus
of evaluating the role of protein NMR spectroscopy in future Structural
Proteomics Centers to be funded by NIH. Our targets include members of large
protein families for which no 3D structural information is available. We
prioritize protein families with representatives in human and higher
eukaryotic genomes because of the important role of these proteins in human
health and model organism biology. NMR data collection at Pacific Northwest
National Laboratories,
in collaboration with Dr. Micheal Kennedy and Dr. John Cort, and the
structures resulting from these data are critical to the
efficacy of this project.

Project Details

Project type
Capability Research
Start Date
2003-04-12
End Date
2004-05-20
Status
Closed

Team

Principal Investigator

Gaetano Montelione
Institution
Rutgers University

Team Members

James Aramini
Institution
Rutgers University

Related Publications

Isern NG, J Xue, JV Rao, JR Cort, and BK Ahring. 2013. "Novel monosaccharide fermentation products in Caldicellulosiruptor saccharolyticus identified using NMR spectroscopy." Biotechnology for Biofuels 6(4):Article No. 47. doi:10.1186/1754-6834-6-47
Oliveira F.C., K. Srinivas, G.L. Helms, N.G. Isern, J.R. Cort, A.R. Goncalves, and B.K. Ahring. 2018. "Characterization of coffee (Coffea arabica) husk lignin and degradation products obtained after oxygen and alkali addition." Bioresource Technology 257. PNNL-SA-131064. doi:10.1016/j.biortech.2018.01.041
Xue J, NG Isern, RJ Ewing, AV Liyu, JA Sears, Jr, H Knapp, J Iversen, DR Sisk, BK Ahring, and PD Majors. 2014. "New generation NMR bioreactor coupled with high-resolution NMR spectroscopy leads to novel discoveries in Moorella thermoaceticum metabolic profiles." Applied Microbiology and Biotechnology. doi:10.1007/s00253-014-5847-8
Yin C, JM Aramini, LC Ma, JR Cort, GVT Swapna, RM Krug, and G Montelione. 2011. "Backbone and Ile-?1, Leu, Val Methyl 1H, 13C and 15N NMR chemical shift assignments for human interferon-stimulated gene 15 protein." Biomolecular NMR Assignments 5(2):215-219. doi:10.1007/s12104-011-9303-8