Materials and Methods for Multivariate Chemical Sensing
EMSL Project ID
3450
Abstract
This research entails an interdisciplinary effort in the development of multivariate trace detection methods suitable for or with the potential to be suitable for field analysis. Specifically, it entails enabling science and technology for chemical sensor arrays, where each chemical sensor is coated with a chemically selective sorptive film material that collects and concentrates analyte molecules on the sensor surface. Research areas within this subject area include the synthesis and characterization of new sensing materials based on polymers or nanomaterials; development of methods to localize sensing materials on specific domains of a device or surface using photopatterning chemistry and methods; investigations of the chemical selectivity of sensor materials and the sensors derived from them; development of sensor arrays and sensor systems; development and evaluation of preconcentrating materials and preconcentrators using them; development of new multivariate data analysis techniques for extracting chemical information from sensor array data; and finally, the development of methods and prototypes that produce data in forms suitable for the most advanced higher order chemometric methods for data processing.
Project Details
Project type
Exploratory Research
Start Date
2003-04-01
End Date
2006-04-02
Status
Closed
Released Data Link
Team
Principal Investigator
Team Members
Related Publications
Bateman, AP. 2011. "Chemical Composition and Photochemical Evolution of Limonene Secondary Organic Aerosol Studied Using High Resolution Electrospray Ionization Mass Spectrometry" Dissertation, University of California, Irvine.
Chang-Graham AL, LT Profeta, TJ Johnson, RJ Yokelson, A Laskin, and J Laskin. 2011. "Case Study of Water-Soluble Metal Containing Organic Constituents of Biomass Burning Aerosol." Environmental Science & Technology 45(4):1257-1263. doi:10.1021/es103010j
Egorov OB, MJ O'Hara, and JW Grate. 2004. "Microwave-Assisted Sample Treatment in a Fully Automated Flow-Based Instrument: Oxidation of Reduced Technetium Species in the Analysis of Total Technetium-99 in Caustic Aged Nuclear Waste Samples." Analytical Chemistry 76(14):3869-3877.
Egorov OB, RS Addleman, MJ O'Hara, TD Marks, and JW Grate. 2005. "Direct Measurement of Alpha Emitters in Liquids using Passivated Ion Implanted Planar Silicon (PIPS) Diode Detectors." Nuclear Instruments and Methods in Physics Research. Section A, Accelerators, Spectrometers, Detectors and Associated Equipment 537(3):600-609.
Grate JW. 2003. "Sorptive Behavior of Monolayer-Protected Gold Nanoparticle Films Containing Alkanethiols and Alkanedithiols." Analytical Chemistry 75(23):6759.
Grate JW, AE Jarrell, DP Chandler, and CJ Bruckner-Lea. 2003. "Automated Sample Preparation method for suspension arrays using renewable surface separations with multiplexed flow cytometry fluorescence detection
." Analytica Chimica Acta 478(1):85-98.
Grate JW, AE Jarrell, DP Chandler, and CJ Bruckner-Lea. 2003. "Erratum to: Automated Sample Preparation Method for Suspension Arrays using Renewable Surface Separations with Multiplexed Flow Cytometry Fluorescence Detection." Analytica Chimica Acta 482(1):147.
Grate JW, NC Anheier, and DL Baldwin. 2005. "Progressive Thermal Desorption of Vapor Mixtures from a Preconcentrator with a Porous Metal Foam Internal Architecture and Variable Thermal Ramp Rates." Analytical Chemistry 77(6):1867-1875.
Gross GM, DA Nelson, JW Grate, and RE Synovec. 2003. "Monolayer-Protected Gold Nanoparticles as a Stationary Phase for Open Tubular Gas Chromatography." Analytical Chemistry 75(17):4558-4564.
Gross GM, JW Grate, and RE Synovec. 2004. "Development and Evaluation of Gold-Centered Monolayer Protected Nanoparticle Stationary Phases for Gas Chromatography." Journal of Chromatography A 1060(1-2):225-236.
Gross GM, JW Grate, and RE Synovec. 2004. "Monolayer-Protected Gold Nanoparticles as an Efficient Stationary Phase for Open Tubular Gas Chromatography using a Square Capillary Model for Chip-Based Gas Chromatography in Square Cornered Microfabricated Channels ." Journal of Chromatography A 1029(1-2):185-192.
Hope JL, KJ Johnson, MA Cavelti, BJ Prazen, JW Grate, and RE Synovec. 2003. "High-Speed Gas Chromatographic Separations with Diaphragm Valve-Based Injection and Chemometric Analysis as a Gas Chromatographic "Sensor"." Analytica Chimica Acta 490:223-230.
J. Laskin, A. Laskin, P.J. Roach, G.W. Slysz, G.A. Anderson, S.A. Nizkorodov, D.L. Bones, and L.Q. Nguyen
High-resolution desorption electrospray ionization mass spectrometry
for chemical characterization of organic aerosols
Analyt. Chem. 82 (2010) 2048-2058. DOI: 10.1021/ac902801f
Karakoti AS, SP Sanghavi, P Nachimuthu, P Yang, and S Thevuthasan. 2011. "Probing the size and environment induced phase transformation in CdSe quantum dots." The Journal of Physical Chemistry Letters 2(22):2925-2929. doi:10.1021/jz201243t
Laskin J, PA Eckert, PJ Roach, BS Heath, SA Nizkorodov, and A Laskin. 2012. "Chemical Analysis of Complex Organic Mixtures Using Reactive Nanospray Desorption Electrospray Ionization Mass Spectrometry." Analytical Chemistry 84(16):7179-7187. doi:10.1021/ac301533z
Nguyen TB, PJ Roach, J Laskin, A Laskin, and S Nizkorodov. 2011. "Effect of Humidity on the Composition of Isoprene Photooxidation Secondary Organic Aerosol." Atmospheric Chemistry and Physics 11(14):6931-3699. doi:10.5194/acp-11-6931-2011
Reid DL, KR Kreitz, MA Stephens, J King, P Nachimuthu, EL Petersen, and S Seal. 2011. "Development of Highly Active Titania-Based Nanoparticles for Energetic Materials." PNNL-SA-80602, Pacific Northwest National Laboratory, Richland, WA. [Unpublished]
Roach PJ, J Laskin, and A Laskin. 2010. "Molecular Characterization of Organic Aerosols Using Nanospray Desorption/Electrospray Ionization-Mass Spectrometry." Analytical Chemistry 82(19):7979–7986. doi:10.1021/ac101449p
Roach PJ, J Laskin, and A Laskin. 2010. "Nanospray Desorption Electrospray Ionization: an Ambient Method for Liquid-Extraction Surface Sampling in Mass Spectrometry." Analyst 135(9):2233-2236.
Roach PJ, J Laskin, and A Laskin. 2011. "Higher-Order Mass Defect Analysis for Mass Spectra of Complex Organic Mixtures." Analytical Chemistry 83(12):4924-4929. doi:10.1021/ac200654j
Wu S, N Tolic, Z Tian, EW Robinson, and L Pasa-Tolic. 2011. "An integrated top-down and bottom-up strategy for characterization protein isoforms and modifications." Chapter 18 in Bioinformatics for Comparative Proteomics: Methods in Molecular Biology, vol. 694, ed. CH Wu and C Chen, pp. 291-304. Springer, New York, NY.
Zheng F, DL Baldwin, LS Fifield, NC Anheier, CL Aardahl, and JW Grate. 2006. "Single-Walled Carbon Nanotube Paper as a Sorbent for Organic Vapor Preconcentration." Analytical Chemistry 78(7):2442-2446.