Pacific Northwest Regional Center of Excellence (PNWRCE)Proteomics, Metabolomics, and Lipidomics Core
EMSL Project ID
34911
Abstract
This Pacific Northwest Regional Center of Excellence (PNWRCE) exists in NIAID Region X. The two inter-related but distinct PNWRCE themes that have been selected reflect not only the scientific strengths at the participating institutions but also the unmet needs in the NIAID biodefense & emerging disease program. This user proposal application will be associated with the second theme of the PNWRCE "The Use of Systems Biology, Functional Genomics and Genetics to Characterize the Pathogen-Host Response for Biodefense and Emerging Disease Organisms". This theme will include 2 projectrs with the overall goal of using systems approaches to identify new targets and therapeutics for Category A-C agents. The goal of the first project, a P01, is to use systems approaches to identify common host susceptibility alleles and signaling circuitry that enhance highly pathogenic pneumonic viruses and Ebola virus replication and pathogenesis and to identify key cellular targets and immune correlates that influence severe disease outcomes. The goal of the second project, a P01, is focused on defining innate immune mechanisms, therapeutic targets, and antiviral compounds that limit flavivirus infection and pathogenesis.
Project Details
Start Date
2009-10-21
End Date
2012-10-21
Status
Closed
Released Data Link
Team
Principal Investigator
Team Members
Related Publications
Kebaabetswe LP, AK Haick, MA Gritsenko, TL Fillmore, RK Chu, SO Purvine, BJM Webb-Robertson, MM Matzke, RD Smith, KM Waters, TO Metz, and TA Miura. 2015. "Proteomic Analysis Reveals Down-Regulation of Surfactant Protein B in Murine Type II Pneumocytes Infected with Influenza A Virus." Virology 438:96-107. doi:10.1016/j.virol.2015.03.045