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Regulated proteolysis and bystander effects in radiation


EMSL Project ID
3523

Abstract

Growing evidence suggests that the number of cells adversely influenced by radiation exposure is greater that those receiving a direct radiation hit. We hypothesize that radiation-induced bystander effects are mediated through stimulated proteolysis of membrane proteins. We will identify and characterize the array of shed proteins released following expsoure of cells to low doses of low LET radiation using a combination of biochemical fractionation and mass spectrometry approaches. The ultimate goal is to quantify the relationship between radiation dose and the types and amounts of shed proteins and their ability to generate a bystander response.

Project Details

Project type
Exploratory Research
Start Date
2003-04-23
End Date
2006-04-27
Status
Closed

Team

Principal Investigator

David Springer
Institution
Pacific Northwest National Laboratory