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High-throughput sequence analysis for communities and environmental sample metagenomics


EMSL Project ID
35595

Abstract

Metagenomes and multiple genome samples include environmental samples from soil and water, community samples involving multiple species (such as human or termite gut) and others. DOE has recognized the likely importance of analyzing metagenome datasets as a key capability for enabling carbon management, renewable fuels, environmental cleanup and a host of other application domains. Understanding complex interactions between physical and chemical processes in these populations requires computational tools and capabilities for basic analysis such as gene sequence alignment, homolog detection, and others. However, metagenomic datasets in many cases already are too large for conventional analysis. Hence DOE capabilities such as ScalaBLAST and the MSC are uniquely suited to address this significant challenge for DOE and a wider research community. The proposed Science Themes work will provide a bridge to make high-throughput sequence analysis available to a wide spectrum of EMSL users for multiple genome and metagenome research.

Project Details

Project type
Capability Research
Start Date
2009-10-01
End Date
2012-09-30
Status
Closed

Team

Principal Investigator

Christopher Oehmen
Institution
Pacific Northwest National Laboratory

Team Members

Christopher Barber
Institution
Pacific Northwest National Laboratory

Arzu Gosney
Institution
Pacific Northwest National Laboratory

Angela Norbeck
Institution
Environmental Molecular Sciences Laboratory

Elena Peterson
Institution
Pacific Northwest National Laboratory

Douglas Baxter
Institution
Environmental Molecular Sciences Laboratory

David Brown
Institution
Environmental Molecular Sciences Laboratory