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Title: The Aspergillus fumigatus proteome during early stages of mammalian lung infection.


EMSL Project ID
42320

Abstract

Overview- The analysis of the Aspergillus fumigatus proteome is of major interest for the research community working on diseases caused by Aspergilli. This planned research will lead to benefits in fundamental knowledge for improving public health in the U.S. and provide new insight to the dynamic biological interactions between pathogen and host. Additionally, since proteomic research on fungi generally is lacking, developing the means to analyze the protein complement, while also gathering complementary knowledge from genomics to drive the analysis of biological pathways and networks, should aid diverse research areas such as bio-energy and carbon sequestration. A close collaboration between leading laboratories in functional genomics, proteomics and aspergillosis will serve as a prototype for other large collaborative efforts to generate proteomics data solving problems of major concern in the U.S. This proposal will harness the expertise of the four leaders in aspergillosis, the genomics capabilities of the Pathogen Functional Genomics Resource Center (PFGRC), the expertise in Aspergillus proteomic sample preparation at the PFGRC, and the world-class mass spectrometry/proteomics technology, resources, and knowledge at PNNL/EMSL.

Project Details

Project type
Exploratory Research
Start Date
2010-10-08
End Date
2011-10-09
Status
Closed

Team

Principal Investigator

Rembert Pieper
Institution
J. Craig Venter Institute

Team Members

Robert Cramer
Institution
Montana State University

William Nierman
Institution
J. Craig Venter Institute

Elaine Bignell
Institution
Imperial College London

Susan Wiedner
Institution
Pacific Northwest National Laboratory

Bernhard Palsson
Institution
University of California, San Diego

Joshua Adkins
Institution
Pacific Northwest National Laboratory