Dynamic Bioresponsive Nanomaterials Captured by Dynamic Transmission Electron Microscopy and High Resolution Optical Microscopy
EMSL Project ID
46907
Abstract
The overarching goal of this research program is to develop discrete, biomolecule encoded nanomaterials capable of responding to their environment through fundamental changes in their morphological, physical and chemical properties. The program seeks to address central problems in the synthesis and characterization of soft materials at the nanoscale by using biological elements to build complexity and advanced electron microscopy approaches for studying these materials in their dynamic state. Furthermore, the program seeks to explore fundamental opportunities and limitations at the biomolecule-soft nanoparticle interface and to study these systems in challenging environments including biological fluids. We propose an approach enabling active, smart uptake and release of molecules from solution via catalytic and other chemical reactions inducing switches in the morphological state of a soft nanoscale carrier. Such an approach is expected to influence materials synthesis, templation, drug delivery, small- and bio-molecule detection, chemical remediation, and self-healing materials. We aim to explore these materials in a variety of settings including as shape-dependent templates for inorganic materials, and as morphology dependent probes and uptake-and-release systems. The facilities at EMSL and expertise of collaborators Dr. James Evans and Dr. Nigel Browning will be an absolutely essential part of the successful development of these materials. Indeed, our team aims to develop dynamic electron microscopy as the gold standard in characterizing soft, dynamic materials.
Project Details
Project type
Large-Scale EMSL Research
Start Date
2012-10-01
End Date
2014-09-30
Status
Closed
Released Data Link
Team
Principal Investigator
Co-Investigator(s)
Team Members