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Uranium Detection and Isotope Ratio Determination Using MALDI-MS


EMSL Project ID
48439

Abstract

The proposed work is in support of a funded NA-24 Next Generation Safeguards Initiative (NGSI) Technology Development project. The safeguards community desires that the mass spectrometric capability of elemental detection and isotope ratio analysis, particularly for uranium, be at or near the inspection sites. Among other things, this will require techniques of minimal sample preparation and ionization for MS analysis. One of the techniques we think promising for this application and wish to study is matrix assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-ToF-MS). We propose using the EMSL User Facility’s MALDI-TOF capability to study the MALDI potential for ionization, detection, and isotope ratio analysis for a variety of elements, including uranium, and using a variety of matrices, including various carbon forms and no matrix.

Project Details

Start Date
2014-03-20
End Date
2014-09-30
Status
Closed

Team

Principal Investigator

Charles Barinaga
Institution
Pacific Northwest National Laboratory

Co-Investigator(s)

George Hager
Institution
Pacific Northwest National Laboratory

Team Members

Kristyn Roscioli
Institution
Pacific Northwest National Laboratory

Related Publications

Hoegg ED, CJ Barinaga, GJ Hager, GL Hart, DW Koppenaal, and RK Marcus. 2016. "Isotope Ratio Characteristics and Sensitivity for Uranium Determinations Using a Liquid Sampling-Atmospheric Pressure Glow Discharge Ion Source Coupled to an Orbitrap Mass Analyzer." Journal of Analytical Atomic Spectrometry 31(12):2355-2362. doi:10.1039/C6JA00163G
Hoegg ED, CJ Barinaga, GJ Hager, GL Hart, DW Koppenaal, and RK Marcus. 2016. "Preliminary Figures of Merit for Isotope Ratio Measurements: The Liquid Sampling-Atmospheric Pressure Glow Discharge Microplasma Ionization Source Coupled to an Orbitrap Mass Analyzer." Journal of the American Society for Mass Spectrometry 27(8):1393-1403. doi:10.1007/s13361-016-1402-4