Infrared Vibrational Nano-Spectroscopy: Pushing Sensitivity and Application Space for Bio-imaging
EMSL Project ID
48682
Abstract
We request access to the scattering scanning near-field optical microscope (s-SNOM) we have developed during a partner proposal, and scanning electron microscope / focused ion beam (SEM/FIB) facility. We propose to perform nanoscale infrared vibrational chemical spectroscopy and imaging on molecular nanostructures and biological molecules. Using FIB to modify s-SNOM probes will allow us to push sensitivity and spatial resolution of the setup to the single molecule limit. From probing nanoscopic molecular ensembles we gain insight into structure, coupling, and dynamics otherwise hidden in macroscopic ensemble measurements. Our work will include making the s-SNOM setup more broadly available for the user program, by developing user protocols, training staff, and making some hardwaremodifications to allow for easier optical alignment and more routine data acquisition.
Project Details
Start Date
2014-11-04
End Date
2015-09-30
Status
Closed
Released Data Link
Team
Principal Investigator
Team Members
Related Publications
Muller EA, B Pollard, and MB Raschke. 2015. "Infrared Chemical Nano-Imaging: Accessing Structure, Coupling, and Dynamics on Molecular Length Scales." Journal of Physical Chemistry Letters 6(7):1275–1284. doi:10.1021/acs.jpclett.5b00108
Muller M ,Kravtsov V ,Paarmann A ,Raschke B M,Ernstorfer R 2016. "Nanofocused Plasmon-Driven Sub-10 fs Electron Point Source" ACS Photonics 3(4):611–619. 10.1021/acsphotonics.5b00710