SSGCID Year IX
EMSL Project ID
49153
Abstract
As witnessed by the recent outbreak of Ebola in Africa, developing new drugs to combat emerging and re-emerging infectious diseases is of upmost importance. The National Institute of Allergy and Infectious Diseases (NIAID) has identified the need to prepare a library of three-dimensional protein structures of potential drug targets that may be used for the structure-based design of new drugs. Towards populating this library NIAID has established two structural genomics centers: The Center for Structural Genomics of Infectious Disease (CSGID) and the Seattle Structural Genomics Center for Infectious Disease (SSGCID). The high-field suite of NMR spectrometers at EMSL will assist the population of the structure library with the high-field NMR data used to determine the solution structure for 2-3 proteins identified as potential drug targets.
Project Details
Start Date
2015-11-09
End Date
2016-09-30
Status
Closed
Released Data Link
Team
Principal Investigator
Related Publications
Bhardwaj G ,Mulligan V K,Bahl C D,Gilmore J M,Harvey P ,Cheneval O ,Buchko G W,Pulavarti S V,Kass Q ,Eletsky A ,Huang PS ,Johnsen W A,Griesen P ,Rocklin G J,Song Y ,Linsky T W,Watkins A ,Rettie S A,Carter L P,Bonneau R A,Olsen J M,Coutsias E ,Correnti C E,Szyperski T ,Craik D J,Baker D 2016. "Accurate de novo design of hyperstable constrained peptides" Nature 538(7625):329-335. 10.1038/nature19791
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