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EDRN Biomarker Reference and Resource Center with the Department of Energy


EMSL Project ID
49639

Abstract

The purpose of the Early Detection Research Network (EDRN) Biomarker Reference and Resource Center (BRRC) is to develop a multiplex quantitative MS-based method, based on LC-SRM-MS for simultaneous detection of ~50 prostate cancer biomarkers in tissue and body fluids; to conduct analytical and clinical validation studies, in collaboration with EDRN investigators; to estimate the utility of the developed assay(s) for early detection and diagnosis of prostate cancer; and to develop identical multiplex quantitative detection of biomarkers in additional cancers, pancreas and breast.

Project Details

Start Date
2016-10-07
End Date
2019-09-30
Status
Closed

Team

Principal Investigator

Tao Liu
Institution
Pacific Northwest National Laboratory

Co-Investigator(s)

Karin Rodland
Institution
Pacific Northwest National Laboratory

Team Members

Patricia Miller
Institution
Pacific Northwest National Laboratory

Josie Hansen
Institution
Pacific Northwest National Laboratory

Josue Cuevas Fernandez
Institution
Pacific Northwest National Laboratory

Thomas Fillmore
Institution
Environmental Molecular Sciences Laboratory

Tujin Shi
Institution
Pacific Northwest National Laboratory

Weijun Qian
Institution
Pacific Northwest National Laboratory

Related Publications

Wang H, CE Barbieri, J He, Y Gao, T Shi, C Wu, AA Schepmoes, TL Fillmore, SS Chae, D Huang, JM Mosquera, WJ Qian, RD Smith, S Srivastava, J Kagan, DG Camp, II, KD Rodland, M Rubin, and T Liu. 2017. "Quantification of Mutant SPOP Proteins in Prostate Cancer Using Mass Spectrometry-Based Targeted Proteomics." Journal of Translational Medicine 15:Article No. 175. doi:10.1186/s12967-017-1276-7