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Optimizing Oil Production in Oleaginous Yeast by Cell-Wide Measurements and Genome-Based Models


EMSL Project ID
49666

Abstract

The team at PNNL is using a combination of flow cytometry, microscopy and lipidomics to establish baseline cell biological and metabolite data on lipid production by the W29 strain of Yarrowia lipolytica. It is important to understand the context of lipid production at both cell biological (for example, compartmentalization of reactions) and metabolite levels as both are important considerations for engineering and modeling of improved strains.

Project Details

Start Date
2016-11-08
End Date
2017-09-30
Status
Closed

Team

Principal Investigator

Scott Baker
Institution
Environmental Molecular Sciences Laboratory

Co-Investigator(s)

Galya Orr
Institution
Environmental Molecular Sciences Laboratory

Team Members

Heino Heyman
Institution
Pacific Northwest National Laboratory

Erin Bredeweg
Institution
Environmental Molecular Sciences Laboratory

Kyle Pomraning
Institution
Pacific Northwest National Laboratory

Young-Mo Kim
Institution
Pacific Northwest National Laboratory

Thomas Metz
Institution
Pacific Northwest National Laboratory

Related Publications

Kerkhoven EJ, YM Kim, S Wei, CD Nicora, TL Fillmore, SO Purvine, BJM Webb-Robertson, RD Smith, SE Baker, TO Metz, and JB Nielsen. 2017. "Leucine biosynthesis is involved in regulating high lipid accumulation in Yarrowia lipolytica." mBio 8(3):Article No. e00857-17. doi:10.1128/mBio.00857-17
Khosravi C, E Battaglia, RS Kun, S Dalhuijsen, J Visser, MV Aguilar-Pontes, M Zhou, HM Heyman, YM Kim, SE Baker, and RP de Vries. 2018. "Blocking hexose entry into glycolysis activates alternative metabolic conversion of these sugars and upregulates pentose metabolism in Aspergillus nidulans." BMC Genomics 19(1):Article No. 214. doi:10.1186/s12864-018-4609-x