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Solid- and solution-state NMR approaches to characterizing the structure of amelogenin.


EMSL Project ID
50629

Abstract

Biomineralization is the process used by living organism to produce minerals with properties not always found in their equivalent inorganically produced counterparts. In vertebrates, mineralized tissues such as bone, cementum, dentin and enamel all consist of calcium phosphate, but have specialized functions as a result of the conditions during formation. Biomineralization proteins are an essential contributor to the resulting materials properties, as they orchestrate the nucleation, growth, and organization of biominerals. Understanding the fundamental mechanisms responsible for this orchestration is important because this knowledge will guide the design of advanced materials in general and new repair or regeneration strategies for biominerals.

Project Details

Start Date
2018-11-07
End Date
2019-09-30
Status
Closed

Team

Principal Investigator

Garry Buchko
Institution
Pacific Northwest National Laboratory

Team Members

Wendy Shaw
Institution
Pacific Northwest National Laboratory

Barbara Tarasevich
Institution
Pacific Northwest National Laboratory

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