BRAVE Agile: WSU-Signatures of Metabolic Dysregulation from Sleep Cycle Disruption
EMSL Project ID
50717
Abstract
Fatigue induced by sleep deprivation, sleep cycle disturbance, or a combination of the two is common in first responder populations. Sleep cycle disruption shifts central and peripheral "clocks" in the human body. These clocks influence multiple biological functions, including basic metabolism. Disruption of basic metabolism during sleep cycle changes can negatively impact performance and health in the short-term and long term. Disruption of metabolism was recently shown in a cohort of 12 humans undergoing a 12 hour sleep cycle reversal. The study, conducted by Dr. Hans Von Dongen at the U.W. Sleep and Human Performance Center (WSU, Spokane) showed some alteration in biological clocks but greater alterations in metabolite profiles. The mechanisms involved remain unknown. We hypothesize that the biological mechanisms involved in metabolic dysregulation can be inferred from combined proteomic and deep metabolomic analysis of existing blood samples using data integration methods including pathway and network analysis.
Project Details
Start Date
2019-02-14
End Date
2020-12-15
Status
Closed
Released Data Link
Team
Principal Investigator
Team Members