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Mechanism of translational regulation and mRNA quality control


EMSL Project ID
50909

Abstract

In all kingdoms of life proteins are synthesized by the large ribonucleoprotein particle known as the ribosome. However it is increasingly clear that the ribosome serves not only as a hub for protein synthesis, but also as a scaffold for factors involved in the maturation and quality control of both the mRNA and nascent polypeptide. The molecular details of how these exogenous factors cooperate with the ribosome to both regulate translation and ensure mRNA quality control remain poorly understood. Here we propose to determine three structures using single particle cryoelectron microscopy that illuminate how mRNA elements can control translation of specific transcripts and how the ribosome facilitates the recognition and degradation of mRNAs.These structures will make critical contributions to our understanding of translational regulation and quality control, a fundamental process with broad biological and biomedical implications.

Project Details

Start Date
2019-05-15
End Date
2019-12-31
Status
Closed

Team

Principal Investigator

Rebecca Voorhees
Institution
California Institute of Technology

Team Members

Caitong Ng
Institution
California Institute of Technology

Kurt Januszyk
Institution
California Institute of Technology

Nancy Meyer
Institution
Oregon Health & Science University