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Medical Defenses Against Emerging Infectious Disease


EMSL Project ID
51053

Abstract

Hemorrhagic fever viruses like Ebola, Marburg, and Lassa cause up to 90% lethality. To study these re-emerging threats to human health and develop the needed vaccines and antivirals, our laboratory employs a spectrum of tools, from atomic structure to model virus infection, combining structural biology and biochemistry with cellular virology, immunology, and field studies in Africa. This proposal describes research aimed at understanding what makes an effective antibody response to these viruses, and how the virus assembles and buds from infected cells with the goal of developing better antibodies and antivirals to inhibit virus infection.

Project Details

Start Date
2019-11-11
End Date
2020-08-10
Status
Closed

Team

Principal Investigator

Erica Saphire
Institution
La Jolla Institute for Immunology

Co-Investigator(s)

Kathryn Hastie
Institution
La Jolla Institute for Immunology

Team Members

Michelle Moss
Institution
La Jolla Institute for Immunology

Tierra Buck
Institution
La Jolla Institute for Immunology

Hal Wasserman
Institution
La Jolla Institute for Immunology

Sara Landeras
Institution
La Jolla Institute for Immunology

Amar Parvate
Institution
Environmental Molecular Sciences Laboratory

Adrian Enriquez
Institution
La Jolla Institute for Immunology

Jingru Fang
Institution
La Jolla Institute for Immunology

Xiaoying Yu
Institution
La Jolla Institute for Immunology

Vamseedhar Rayaprolu
Institution
Oregon Health & Science University

Michael Norris
Institution
La Jolla Institute for Immunology

Haoyang Li
Institution
La Jolla Institute for Immunology

Zhe Salie
Institution
La Jolla Institute for Immunology

Heather Callaway
Institution
La Jolla Institute for Immunology

Ruben Diaz
Institution
La Jolla Institute for Immunology

Emilia Arturo
Institution
La Jolla Institute for Immunology

Harry Scott
Institution
Oregon Health & Science University