Cryo-EM study of human serotonin transporter in complex with serotonin

The objectives of this research are to elucidate the structures of a human serotonin transporter by single particle cryo-EM in multiple distinct conformational states in which the transporter is bound with selected agonists, antagonists or allosteric modulators. These studies will not only reveal the overall architectures and structures of the human serotonin transporter but they will also provide detailed, structure-based insight into its mechanisms of action.