Cryo-EM of Metabolic Enzymes for Drug Design
EMSL Project ID
51281
Abstract
Given the high failure rate of drug candidates that enter clinical trials and the length of time involved, there is an urgent need to develop new approaches to lower failure rates. Some of the reasons for failure derive from ineffective targeting of the relevant disease-linked proteins in their physiological, native states, in addition to toxic side-effects from off-target reactions. The hypothesis underlying our approach is that by better characterization of the native structure and multiple conformational states of key disease-linked proteins, we will be more successful at targeting, reducing the cost and time for discovering new drugs. Atomic resolution cryo-EM is uniquely positioned to provide this kind of information. This proposal is aimed at establishing a platform for drug discovery for targeting key metabolic enzymes that underlie many diseases ranging from cancer to infectious diseases with cryo-EM.
Project Details
Start Date
2020-02-15
End Date
2021-03-17
Status
Closed
Released Data Link
Team
Principal Investigator
Team Members