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Structural studies of the bacterial ribosome: regulation of gene expression, stress tolerance and antibiotic resistance.


EMSL Project ID
51302

Abstract

In every living organism, protein synthesis (translation) is catalyzed by a large, dynamic RNA-protein macromolecular complex called the ribosome. We use biochemical, structural and functional approaches to understand the molecular mechanisms that govern biological fitness during translation including miscoding, mRNA frameshift events and antibiotic resistance by modification of the ribosome. These studies aim to understand the mechanistic basis for the regulation and dysregulation of protein synthesis. This is important not only because translation is a fundamental biological process in all cells, but also because many clinically relevant antibiotics target the ribosome and defects in ribosome biogenesis and translation are implicated in a wide variety of diseases.

Project Details

Start Date
2020-03-15
End Date
2021-03-17
Status
Closed

Team

Principal Investigator

Christine Dunham
Institution
Emory University

Co-Investigator(s)

Graeme Conn
Institution
Emory University

Team Members

Ian Pavelich
Institution
Emory University

Ha A Nguyen
Institution
Emory University

Pooja Srinivas
Institution
Emory University

Harry Scott
Institution
Oregon Health & Science University

Trevor Moser
Institution
Environmental Molecular Sciences Laboratory