Structural investigation of the PI3K-gamma isoform kinase
EMSL Project ID
51305
Abstract
One of the major developments in cancer treatment has been the use of cancer immunotherapy to utilize the immune system to target and destroy cancer cells. The phosphoinositide 3-kinase (PI3K) pathway is at the crossroads of both cancer development and immune regulation. Inhibition of the PI3K gamma isoform is able to act as a switch that can reprogram the tumour microenvironment to target cancer cells. This is a powerful approach to promote the immune system to generate an anti-cancer response, and the development of specific inhibitors being an excellent strategy for cancer therapeutics.This proposal focuses on studying the structural and dynamic basis of regulation of PI3K gamma, with a major focus on the development of specific small molecule inhibitors. One of our major goals will be in defining the molecular mechanisms that control how this enzyme is activated, and how it can be misregulated in human disease. This will be approached using a cutting-edge synergy of state of the art biochemical and biophysical methods including Cryo-Electron Microscopy, X-ray crystallography, and Hydrogen Deuterium Exchange mass spectrometry.
Project Details
Start Date
2020-03-15
End Date
2021-03-17
Status
Closed
Released Data Link
Team
Principal Investigator
Team Members