Elucidating Native Structures of Enveloped Virus Glycoproteins using Cryo-EM and Tomography
EMSL Project ID
51345
Abstract
We seek to understand the entry mechanisms of enveloped viruses for three viral families having broad health impact worldwide: coronaviruses such as SARS CoV 2, retroviruses such as HIV 1, and orthomyxoviruses such as influenza A H1N1. The project aims to determine sub-nanometer structures of envelope glycoprotein on native non-infectious pseudovirions. This advance will allow investigating the nature of the interaction between viral glycoproteins and human host receptors, and studying the vulnerability of these interactions to antibody-mediated neutralization. The aims of this project are related to our overall program to improve drug treatments and for rational vaccine design.
Project Details
Start Date
2020-05-15
End Date
2021-03-17
Status
Closed
Released Data Link
Team
Principal Investigator
Team Members