Structural basis of ligand gating mechanisms in TRPM4 and TRPML1 channels
EMSL Project ID
51776
Abstract
Ion transfer across biological membranes is an essential physiological process mediated by ion channels and is central to nerve excitation, muscle cell contraction, signal transduction, and hormone secretion. Gating and ion selectivity are two fundamental properties central to ion channel functions. My laboratory has a longstanding interest in studying the structural basis of these two fundamental properties among tetrameric cation channels. Members of this large ion channel family, including the K+, Ca2+, Na+, TRP and cyclic nucleotide-gated channels, contain four membrane-spanning subunits or domains that form a central pore for selective ion transfer. In this proposal, we aim to study the structural basis of ligand gating mechanisms in two physiological important TRP (transient receptor potential) channels, namely TRPM4 and TRPML1.
Project Details
Start Date
2020-12-15
End Date
2021-03-17
Status
Closed
Released Data Link
Team
Principal Investigator
Team Members