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Structural basis of ligand gating mechanisms in TRPM4 and TRPML1 channels


EMSL Project ID
51776

Abstract

Ion transfer across biological membranes is an essential physiological process mediated by ion channels and is central to nerve excitation, muscle cell contraction, signal transduction, and hormone secretion. Gating and ion selectivity are two fundamental properties central to ion channel functions. My laboratory has a longstanding interest in studying the structural basis of these two fundamental properties among tetrameric cation channels. Members of this large ion channel family, including the K+, Ca2+, Na+, TRP and cyclic nucleotide-gated channels, contain four membrane-spanning subunits or domains that form a central pore for selective ion transfer. In this proposal, we aim to study the structural basis of ligand gating mechanisms in two physiological important TRP (transient receptor potential) channels, namely TRPM4 and TRPML1.

Project Details

Start Date
2020-12-15
End Date
2021-03-17
Status
Closed

Team

Principal Investigator

Youxing Jiang
Institution
University of Texas Southwestern Medical Center

Team Members

Yan Wang
Institution
University of Texas Southwestern Medical Center

Yan Han
Institution
University of Texas Southwestern Medical Center

Jing Xue
Institution
University of Texas Southwestern Medical Center