Metabolic Landscape of the Aging Lung
EMSL Project ID
60068
Abstract
Aging is a major risk factor for the majority of acute and chronic diseases of the lung, including emphysema, pulmonary fibrosis, and lower respiratory tract infections. In this study we will leverage advanced omics technologies at PNNL to test the hypothesis that normal human aging is associated with altered metabolic sensing that predisposes to cellular senescence and stem cell dysfunction, and that the age-related disease, IPF, will demonstrate features of accelerated aging. Proteomics, glycomics, lipidomics/metabolomics analyses of tissues, cells, and plasma will be performed using mass spectrometry. Overall, these studies will fundamentally advance our knowledge of critical metabolic nodes and sensing pathways that may involve alterations in redox state, AMPK activation, sirtuins, O-GlcNAcylation, and lipid signaling in the biology of lung aging.
Project Details
Start Date
2021-05-04
End Date
2023-09-30
Status
Closed
Released Data Link
Team
Principal Investigator
Team Members