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Virtual Proteomics (ViP): Integrative modeling of protein assemblies in a cell with constraints from proteomic data and reconstructed images from cryo-electron tomography


EMSL Project ID
60202

Abstract

Abstract

The objective of the proposed research is to advance the spatial knowledge of higher-order protein assemblies in a cell by integrating improved image reconstruction from cryo-electron tomography and proteomic data from high-throughput mass spectrometry as parameter constraints with the approach of physical modeling and statistical inference.

Project Details

Start Date
2021-08-03
End Date
N/A
Status
Active

Team

Principal Investigator

Margaret Cheung-Wyker
Institution
Environmental Molecular Sciences Laboratory

Team Members

Malio Nelson
Institution
University of Washington

Katharine Baldwin
Institution
Environmental Molecular Sciences Laboratory

Arsam Firoozfar
Institution
Environmental Molecular Sciences Laboratory

Jesse Fichman
Institution
Environmental Molecular Sciences Laboratory

Eve Johnson
Institution
University of Washington

Jiayi Wang
Institution
University of Washington

Liam Mackey
Institution
Environmental Molecular Sciences Laboratory

Yasmene Elhady
Institution
University of Washington

Chengxuan Li
Institution
University of Washington

Jules Nde
Institution
University of Washington

August George
Institution
Environmental Molecular Sciences Laboratory

Doo Nam Kim
Institution
Pacific Northwest National Laboratory

Mowei Zhou
Institution
Environmental Molecular Sciences Laboratory

Trevor Moser
Institution
Environmental Molecular Sciences Laboratory

James Evans
Institution
Environmental Molecular Sciences Laboratory

Ljiljana Pasa-Tolic
Institution
Environmental Molecular Sciences Laboratory