Seattle Structural Genomics Center for Infectious Diseases – Year XV
EMSL Project ID
60239
Abstract
The rapid spread of SARS-CoV-2 through-out the world and its life-changing impact on the day-to-day lives of Americans punctuate the need to be ever cautious of the emergence of new epidemic infectious diseases. COVID-19, along with the emergence of multi-drug resistant strains of infectious agents, makes developing new drugs to combat emerging and re-emerging infectious diseases of upmost importance. The National Institute of Allergy and Infectious Diseases (NIAID) has identified the need to prepare a library of three-dimensional protein structures of potential drug targets that may be used for the structure-based design of new drugs. Towards populating this library NIAID has established two structural genomics centers: The Center for Structural Genomics of Infectious Disease (CSGID) and the Seattle Structural Genomics Center for Infectious Disease (SSGCID). The armada of high-field NMR spectrometers at EMSL will assist the population of the structure library by providing NMR data to determine the solution structure for proteins identified as potential drug targets.
Project Details
Start Date
2021-12-02
End Date
2022-09-30
Status
Closed
Released Data Link
Team
Principal Investigator
Related Publications
C. Mandel, H. Yang, G.W. Buchko, J. Abendroth, N. Grieshaber, T. Chiarelli, S. Grieshaber, A. Omsland (2022) Structure, activity, and expression of a mono-cysteine DksA variant in Chlamydia trachomatis. Pathogens and Diseases, 80(1):ftac007.
Jan Abendroth, Garry W. Buchko, Hyung J. Kim, Fong Ning Liew, Joline N. Nguyen. 2022. "Structural Characterization of Cytochrome c′β‐Met from an Ammonia-Oxidizing Bacterium." Biochemistry 61 (7):563-574. https://doi.org/10.1021/acs.biochem.1c00640