Determining the roles of sphingolipids in phagocytosis
EMSL Project ID
60632
Abstract
Phagocytosis is a conserved cellular process that is not only critical to ingest and eliminate invading microbial pathogens but also to clear effete cells, and cellular debris. Phagocytosis also relies on spatial-temporal modification of lipids that compose the plasma membrane. These include the signaling lipid molecules the phosphoinositides (PIs). However, the roles of other lipids including sphingolipids (SPLs), molecules enriched at the outer leaflet of the plasma membrane, in phagocytosis remain largely unknown. We hypothesize that both structural and bioactive SPLs are critical determinant factors in phagocytosis and promote the recruitment of phagosomal proteins to the phagocytic synapse. The goal of the proposal is to systematically perturb the key SPL pathways of the host to uncover their function in phagocytosis. This contribute towards goal we aim to identify determine the SPL species and other complex membrane lipids required for phagocytosis
Project Details
Start Date
2022-10-24
End Date
N/A
Status
Active
Released Data Link
Team
Principal Investigator
Team Members