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Understanding structure-function relationship in enzymes by designing artificial enzymes


EMSL Project ID
60806

Abstract

We propose to study how the protein environment affects functionality by designing an artificial enzyme. We will investigate the artificial enzyme Rh-LmrR which comprises an Rh-based molecular complex covalently bound to the LmrR protein scaffold. This enzyme converts CO2 to formate in aqueous solution. We will use computational chemistry tools to understand how the protein scaffold activates the molecular complex in water and then redesign the enzyme for higher activity.

Project Details

Project type
Large-Scale EMSL Research
Start Date
2023-10-01
End Date
N/A
Status
Active

Team

Principal Investigator

Bojana Ginovska
Institution
Pacific Northwest National Laboratory

Co-Investigator(s)

Jack Fuller
Institution
Pacific Northwest National Laboratory

Simone Raugei
Institution
Pacific Northwest National Laboratory

Wendy Shaw
Institution
Pacific Northwest National Laboratory

Team Members

David Ryan
Institution
Pacific Northwest National Laboratory

Gregory Schenter
Institution
Pacific Northwest National Laboratory