Next-generation stimulated Raman scattering (SRS) microscopy to overcome photodamage and resolution limitations for real-time tracking of lipid/carbohydrate interfaces in plants, algae, and fungi
EMSL Project ID
60828
Abstract
We will enhance the sensitivity through quantum- enhanced noise suppression in the SRS signal. The enhanced sensitivity will benefit from lower excitation power, lower detection concentrations, and higher image acquisition times without photodamage. The enhanced signal-to-noise ratio will also benefit the structured illumination microscopy to provide better spatial resolution. We will utilize this team's cutting-edge quantum squeezed light sources and state-of-the- art SRS microscopes to guarantee enhancement over its classical peers. EMSL role will be to perform metabolomics and cutting-edge mass spectrometry imaging (MSI) to validate this system
Project Details
Start Date
2023-04-24
End Date
N/A
Status
Active
Released Data Link
Team
Principal Investigator
Team Members