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Next-generation stimulated Raman scattering (SRS) microscopy to overcome photodamage and resolution limitations for real-time tracking of lipid/carbohydrate interfaces in plants, algae, and fungi


EMSL Project ID
60828

Abstract

We will enhance the sensitivity through quantum- enhanced noise suppression in the SRS signal. The enhanced sensitivity will benefit from lower excitation power, lower detection concentrations, and higher image acquisition times without photodamage. The enhanced signal-to-noise ratio will also benefit the structured illumination microscopy to provide better spatial resolution. We will utilize this team's cutting-edge quantum squeezed light sources and state-of-the- art SRS microscopes to guarantee enhancement over its classical peers. EMSL role will be to perform metabolomics and cutting-edge mass spectrometry imaging (MSI) to validate this system

Project Details

Start Date
2023-04-24
End Date
N/A
Status
Active

Team

Principal Investigator

Christopher Anderton
Institution
Environmental Molecular Sciences Laboratory

Team Members

Bryon Donohoe
Institution
National Renewable Energy Laboratory

Jonathan Jacobs
Institution
The Ohio State University

Dusan Velickovic
Institution
Environmental Molecular Sciences Laboratory