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Identification of HLA-A29 peptides bound to the MHC-Class I groove in birdshot uveitis patient leukocytes.


EMSL Project ID
60878

Abstract

Birdshot chorioretinopathy (BSCR) is an autoimmune disorder that causes blindness. All patients with BSCR have the HLA-A29 allele encoded by the HLA-A29 MHC Class I receptor. However, less than 1% of people with HLA-A29 alleles have BSCR. Therefore, the A29 allele is necessary, but not sufficient for disease. That an MHC Class I receptor is so strongly implicated in BSCR suggests that Class I peptide presentation, and CD8+ T cell receptors play a key role in the mechanism of BSCR. The long-term goal of this project is to identify differences in peptides presented by circulating antigen presenting cells in BSCR(+) patients and BSCR(-) patients. Differences in the self and non-self Class I-presented peptides in these two patient populations will be interrogated for mechanistic roles in development of chorioretinopathy.

Project Details

Start Date
2023-05-12
End Date
2023-10-01
Status
Closed

Team

Principal Investigator

John Melchior
Institution
Pacific Northwest National Laboratory

Team Members

Isaac Attah
Institution
Pacific Northwest National Laboratory