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Iron, Ferroptosis and Ovarian Cancer


EMSL Project ID
61011

Abstract

The goal of this proposal is to provide mechanistic information on the role of iron in ferroptosis, test how manipulating pathways of iron and lipid metabolism impact ferroptosis, and explore how this information can be used to facilitate the transition of ferroptosis inducers to a viable anti-tumor strategy in treatment of ovarian cancer. It should be noted that anti-cancer drugs in current clinical use have recently been shown to trigger ferroptosis. Thus our work can be used not only to optimize the development of new ferroptosis-inducing drugs, but to more effectively re-deploy existing drugs to treat ovarian cancer. In this study we will leverage advanced imaging mass spectrometry and global lipidomics technologies at PNNL to characterize spatial localization of iron and lipids as well as global lipidome of normal and cancer cells. Imaging and global lipidomics analyses of cells provided by the Torti laboratory at the University of Connecticut will be performed using mass spectrometry.

Project Details

Start Date
2023-10-19
End Date
N/A
Status
Active

Team

Principal Investigator

Christopher Anderton
Institution
Environmental Molecular Sciences Laboratory

Team Members

Jeremy Bougoure
Institution
Environmental Molecular Sciences Laboratory

Brittney Gorman
Institution
Environmental Molecular Sciences Laboratory

Jennifer Kyle
Institution
Pacific Northwest National Laboratory