Projects

Determination of Cr and O diffusion coefficients in (Co,Mn)3O4 coatings for IT-SOFC Steel Interconnects

Lead Institution

Montana State University

Principal Investigator

Richard Smith

Project type

Large-Scale EMSL Research

The long term performance and performance stability of the intermediate temperature solid oxide fuel cells (IT-SOFC) are closely connected to the corrosion resistance and thermal stability of the…

DNA methylation-dependent patterns of histone post-translational modification

Lead Institution

Indiana University - Bloomington

Principal Investigator

Craig Pikaard

Project type

Large-Scale EMSL Research

In eukaryotes, chromosomal DNA does not exist as a naked molecule, but is complexed with proteins to form chromatin. As a first step in chromatin formation, 167 bp of DNA is wrapped around a histone…

Advanced Diagnostic Studies of Lithium Ion Batteries Using In Situ and Ex Situ NMR Spectroscopies

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Jian-zhi Hu

Project type

Large-Scale EMSL Research

Energy shortage is a critical problem in the 21th century. Developing highly efficient and high capacity energy storage device such as lithium iron battery is of considerable interest to the nation…

Nano- and Atomic-Level Engineered Adsorbent, Catalyst, and Membrane Materials for Energy and Environmental Application

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Wei Liu

Project type

Large-Scale EMSL Research

This proposal is to gain access to EMSL resources for processing and characterization of highly-engineered solid adsorbent, catalyst and membrane materials, and to develop correlation of their…

Photoswitchable Dyes and Nanoparticles Enable High Resolution and Accurate Fluorescent Probes for Cell Imaging

Lead Institution

Washington State University

Principal Investigator

Alexander Li

Project type

Large-Scale EMSL Research

We have developed photoswitchable dyes and nanoparticles for high-resolution and high-accuracy cell imaging. Upon photoactivation, the fluorescent molecules switch either emission colors or between…

Development and Applications of Novel Approaches for Analysis of Organic Aerosols using High-resolution Mass Spectrometry.

Lead Institution

Fudan University

Principal Investigator

Xin Yang

Project type

Large-Scale EMSL Research

The objective of the proposed research is to develop and apply new approaches for detailed, molecular-level characterization of the chemical composition of organic aerosols using atmospheric pressure…

Linking Microscopic to Macroscopic Adsorption/Desorption Behavior for Uranium on Environmental Materials

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Kevin Rosso

Project type

Large-Scale EMSL Research

This Science Theme proposal requests EMSL access for a subtask on an existing funded project at PNNL. The task is focused on determination of molecular-scale adsorption, desorption, and…

A Metabolomic Approach For Characterizing Methylenetetrahydrofolate Reductase Mutations And Possible Outcomes For The Treatment of Related Diseases

Lead Institution

Washington State University Tri-Cities

Principal Investigator

Kathleen McAteer

Project type

Large-Scale EMSL Research

N5,N10-Methylenetetrahydrofolate reductase (MTHFR) is a flavoprotein that catalyzes the conversion of N5,N10-methylenetetrahydrofolate to N5-methyltetrahydrofolate. This reaction is required for the…

Diffusion Measurements in Polymers and Their Composites

Lead Institution

Washington State University

Principal Investigator

Lloyd Smith

Project type

Large-Scale EMSL Research

Moisture can play a significant role in influencing the mechanical behavior and long-term durability of composites. The current proposal aims to understand the basic concepts of moisture transport in…

Thyroid Hormone and Myocardial Substrate Use with Aging

Lead Institution

Seattle Children's Research Institute

Principal Investigator

Michael Portman

Project type

Large-Scale EMSL Research

Thyroid hormone regulates cardiac function through binding to its nuclear receptors (TRs). Classically, the ligand bound receptors in turn bind to response elements and control transcription of key…

High resolution mass spectrometry of high molecular weight compounds formed via the heterogeneous reaction of OH with simple organic aerosols

Lead Institution

Lawrence Berkeley National Laboratory

Principal Investigator

Kevin Wilson

Project type

Large-Scale EMSL Research

Our objective is to determine the fundamental reaction rates and mechanisms for the heterogeneous oxidation of organic aerosols by OH radicals. Single component organic aerosols particles are used…

Ferromagnetic study of ZnO based heterojunctions

Lead Institution

Portland State University

Principal Investigator

Nadarajah Athavan

Project type

Large-Scale EMSL Research

The search for spintronics materials that combine semiconducting and ferromagnetic properties, dilute magnetic semiconductors (DMS), is presently one of the most relevant fields in magnetism…

Chemistry of Aerosols in the North Slope of Alaska: ISDAC 2008 study.

Lead Institution

Lawrence Berkeley National Laboratory

Principal Investigator

Mary Gilles

Project type

Large-Scale EMSL Research

The ISDAC (Indirect and Semi-Direct Aerosol Campaign) field study carried out in the North Slope of Alaska 2008 was a collaborative effort sponsored by the DOE Atmospheric Radiation Measurement (ARM)…

Determination of enhanced ZnO nucleation and growth by modeling, simulation and MOCVD under UV irradiation

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Vincent Woods

Project type

Large-Scale EMSL Research

ZnO is a wide-band-gap semiconductor with band gap energy, Eg, of 3.37 eV at room temperature. It possesses a large exciton binding energy of 60 meV. Considerable excitement has been associated with…

Understanding the dynamics of the cyclophilins family of enzymes and their interactions with their CD147 receptor.

Lead Institution

University of Colorado at Denver

Principal Investigator

Elan Eisenmesser

Project type

Large-Scale EMSL Research

Enzyme motions associated with catalysis have been found to occur even in the absence of substrates and localize to similar regions. This inherent flexibility may allow important conformations to be…

Pathways and fate of individual nanoparticles in vivo; a whole organism approach

Lead Institution

Oregon State University

Principal Investigator

Robert Tanguay

Project type

Large-Scale EMSL Research

The growing commerce in micro- and nanotechnology is expected to increase human exposure to submicrometer and nanoscale particles, including certain forms of amorphous silica nanoparticles. Adverse…

Tissue distribution and fate of nanoparticles following in vivo exposure

Lead Institution

Procter and Gamble

Principal Investigator

Katherine Sarlo

Project type

Large-Scale EMSL Research

The growing commerce in micro- and nanotechnology is expected to increase human exposure to submicrometer and nanoscale engineered particles. Adverse effects of submicrometer and nanoscale particles…

POSTTRANSLATIONAL MODIFICATIONS FOR EARLY DETECTION OF BREAST CANCER

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Richard Zangar

Project type

Large-Scale EMSL Research

Breast cancer is the most common cancer in women and is the second leading cause of death due to cancer. The goal of this study is to use proteomics to identify post-translational modifications …

EFFECT OF STRUCTURE AND IMPURITIES ON CHARGE TRANSFER REACTIONS IN SOLID STATE ELECTROCHEMICAL DEVICES

Lead Institution

Boston University

Principal Investigator

Srikanth Gopalan

Project type

Large-Scale EMSL Research

Interfaces between solid state electrodes, electrolytes, and the gas phase play an important role in the functioning of many solid state electrolyte devices. In actual devices, porous electrodes are…

Photoemission Electron Microscopy of Small Polaron Formation on NaCl Islands on Cu (111)

Lead Institution

University of Minnesota

Principal Investigator

Xiaoyang Zhu

Project type

Large-Scale EMSL Research

Our recent paper describes the time-dependence of small polaron formation at the interface of a metal insulator system. This result is unique in that the observed interfacial polaron formation has…