Projects

Connecting the Physicochemical Properties with Ice Nucleation Properties of Secondary Organic Aerosols (SOAs) Formed from Multiphase Chemical Processes

Lead Institution

Texas A&M University

Principal Investigator

Yue Zhang

Project type

Large-Scale EMSL Research

Organic aerosols (OA), especially secondary organic aerosols (SOA), make up a large fraction of tropospheric fine particulate matter (PM) and up to 80% of the total fine PM in the upper troposphere…

Probing the Martian atmosphere and hydrosphere using micro- and nano-scale analyses

Lead Institution

Royal Ontario Museum

Principal Investigator

Kimberly Tait-Sena

Project type

Large-Scale EMSL Research

Mars has long been the primary target in the search for possible life beyond our planet, mainly due to widespread evidence that water once flowed on its surface. Water is an essential ingredient for…

NMR for Catalyst Studies

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Charles Peden

Project type

Large-Scale EMSL Research

A detailed understanding of the mechanisms involved in a catalytic reaction requires that we identify the nature of the active sites and of reaction intermediates, and that we probe dynamic processes…

Multifunctional Nanostructures for Nano-Biotechnology Applications

Lead Institution

Boise State University

Principal Investigator

Alex Punnoose

Project type

Large-Scale EMSL Research

Our group at Boise State University is preparing powder and thin film samples of metla and metal oxide nanoparticles in pure and transition - metal - doped forms. We are also interested in preparing…

Biomarkers of malaria infection

Lead Institution

Seattle Biomedical Research Institute

Principal Investigator

Michal Fried

Project type

Large-Scale EMSL Research

This application is for the continuation and expansion of proposal 8211 "Membrane proteins of placental parasites". P. falciparum causes severe syndromes by adhering to endothelium and…

Test Measurements and Approaches for Enhancing Information Available from Surface Analysis of Oxides, nanoparticles and organic materials analysis

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Donald Baer

Project type

Large-Scale EMSL Research

This activity involves extending the state of the art in surface analysis by expanding the understanding of equipment capability, testing new approaches to instrument calibration, operation and data…

Ion Channeling Studies of Epitaxial Oxide Films and Gas-Solid interfaces.

Lead Institution

Wayne State University

Principal Investigator

Karur Padmanabhan

Project type

Large-Scale EMSL Research

The proposal addresses two important research areas using the on RBS, ion channeling and nuclear reaction analysis. EMSL ion accelerator facility will be used for both projects. The first involves…

Identification and Validation of Protein Profiles Associated with Therapy-Resistance in Breast Cancer

Lead Institution

Erasmus University Medical Center, Rotterdam

Principal Investigator

Arzu Umar

Project type

Large-Scale EMSL Research

Successful treatment of breast cancer is hampered by the occurrence of drug resistance in approximately 50% of patients with advanced recurrent disease. The ultimate goal of proposed work is to…

PNNL Metabolomics Measurement and Validation Development for Renewable Energy Research

Lead Institution

Washington State University

Principal Investigator

Paul Majors

Project type

Large-Scale EMSL Research

This capability-development project will provide PNNL and DOE with a unique live / in-situ metabolomics capability for microbial bioenergy development. The technology will be applicable for the…

Host Cell Interactions with Human Infectious Diseases, Straub

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Timothy Straub

Project type

Large-Scale EMSL Research

Pathogenesis is a complex biological process between the human host and the infectious disease agent. In our previous successful collaboration with EMSL scientists (EMSL Project 16297), which lead…

Analysis of the Proteome and Transcriptome of In Vivo Brucella spp., Yersinia pestis, Francisella tularensis, Mycobacterium spp., Salmonella typhimurium Infected Ileum

Lead Institution

Texas A&M University

Principal Investigator

Leslie Adams

Project type

Large-Scale EMSL Research

The host responses to Brucella spp., Yersinia pestis, Francisella tularensis, Mycobacterium spp., Salmonella typhimurium and the pathogen responses to the host play major roles in the outcome of…

Characterization of synthesised mixed valent natuarlly occuring Fe-films

Lead Institution

University of Greifswald

Principal Investigator

Georg Grathoff

Project type

Large-Scale EMSL Research

A new mixed-valent (ferric-ferrous) precursor to ferrihydrite, a floating iron film often misidentified as an oil film, has been identified and preliminarily characterized. This mixed-valent iron…

NMR Study of Novel Hydrogen Storage Materials

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Z. Gary Yang

Project type

Large-Scale EMSL Research

In the past two years, PNNL has collaborated with the University of Connecticut with aims to develop nanostructured hydrides and to obtain insights into the hydrogen desorption and sorption of the…

The electronic structure and dynamics of photocatalytic and electronic interfaces

Lead Institution

University of Pittsburgh

Principal Investigator

Hrvoje Petek

Project type

Large-Scale EMSL Research

IThe electronic structure of unoccupied states and defects represents one of the most experimentally and theoretically demanding challenges in the science of interfacial phenomena. Here we propose a…

The Reduction of Uranyl and Chromate to Insoluble Species by Green Rust and Other Ferrous Hydroxides Surfaces

Lead Institution

State University of New York at Stony Brook

Principal Investigator

Martin Schoonen

Project type

Large-Scale EMSL Research

Electron transfer reactions play an important role in determining of the fate of many environmental contaminants. Reduction from high-oxidation states (+5/+6), where the metal is stabilized in…

Age related post translational modifications to proteins that alter protein complexes determined by FTICR-MS

Lead Institution

University of Tennessee

Principal Investigator

Heather Smallwood

Project type

Large-Scale EMSL Research

Reactive oxygen species (ROS) are central to the immune response; however, ROS also produce posttranslational modifications (PTMs) on intracellular proteins in the state of chronic inflammation we…

Surface Migration of Additives in Polymers

Lead Institution

Cornell University

Principal Investigator

Lynden Archer

Project type

Large-Scale EMSL Research

Field-induced migration of oligomers dispersed in a host polymer is a promising method for modifying the host polymer's surface to improve properties such as paintability, biocompatibility, and…

Synthesis of photoactive metal oxide films for study using time-resolved x-ray techniques

Lead Institution

Stanford Linear Accelerator Center

Principal Investigator

Kelly Gaffney

Project type

Large-Scale EMSL Research

We propose to study cuprous oxide thin film growth and expand the scope of the work to other transition-metal-oxide systems. Transition-metal oxides have many interesting photophysical and…

High Resolution 1H NMR Metabolomics Using Slow and Ultra Slow Magic Angle Spinning

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Jian-zhi Hu

Project type

Large-Scale EMSL Research

Recently, we developed new so-called slow-MAS (magic angle spinning) NMR techniques that significantly enhance the spectral information in biofluids, intact excised tissues, organs and live small…

Development of Microscopically-Based Models for Prediction of the Impact of Surface Grain Coating on Mineral Dissolution and Leaching Rates

Lead Institution

Washington State University

Principal Investigator

Andrew Felmy

Project type

Large-Scale EMSL Research

Over the past two decades, molecular level information on the composition, structure, and nature of impurities in naturally occurring mineral phases and anthropogenic subsurface materials has become…