Projects

As a scientific user facility, the Environmental Molecular Sciences Laboratory (EMSL) provides expertise, instrumentation, and resources to 250 projects each year.

EMSL projects displayed on the EMSL web site project page reflect project abstracts and information migrated to this page before April 30, 2024. To review current and past EMSL user projects, visit EMSL Science Central.™

Forensic Proteomics of Viruses

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

David Wunschel

The previous proteomic analysis of vaccinia virus (VV) and Monkeypox viruses has indicated that a significant amount of host cellular protein associates itself with virus preparations. Some of these…

Using electron paramagnetic resonance to study iron binding sites with alpha-synuclein, a protein marker for Parkinson's disease

Lead Institution

California State University, Los Angeles

Principal Investigator

Feimeng Zhou

Project type

Exploratory Research

In Parkinson's disease, the brains of affected patients were found to contain aggregated alpha-synuclein (a-syn) protein and high levels of iron (Fe2+ and Fe3+). Iron was found to binding a-syn,…

Biophysical Basis of a Low Temperature Transition in Protein Hydrophobic Core

Lead Institution

University of Alaska at Anchorage

Principal Investigator

Liliya Vugmeyster

Project type

Exploratory Research

Proteins undergo a number of changes when their temperature is dropped from the physiological range to much lower values. One of the most well-known dynamical changes undergone by proteins in a solid…

Isoprene Research Campaign: Making Isoprene from Biomass Material using Bacillus Species

Lead Institution

Washington State University Tri-Cities

Principal Investigator

Birgitte Ahring

Project type

Research Campaign

The overarching goal of this project is to understand the pathway of isoprene production in Bacillus subtilis, to serve as the basis for genetically modifying the pathway to substantially increase…

GC-MS Analysis of Alkaline Cellulose Degradation Products

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

John Cort

Project type

Exploratory Research

Degradation of cellulose and other polysaccharides in alkaline conditions and at elevated temperatures yields mixtures of compounds containing carboxylic acid and/or alcohol functional groups. These…

Advanced IMPROVE Studies

Lead Institution

Desert Research Institute

Principal Investigator

Douglas Lowenthal

Project type

Exploratory Research

This EMSL proposal will contribute to ongoing research sponsored by EPRI to elucidate aerosol chemical and physical properties which contribute to haze in U.S. national parks. This research tests…

Analysis of Proteins and Metabolites of Unknown Samples - Dr. Karen Wahl PI

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Nancy Valentine

The objectives of this proposal are to use the skills and expertise resident at PNNL to develop additional tools to screen bioforensics samples for unknown biothreat agents and to strengthen and…

First-principles simulation of corrosion processes relevant to long-term technetium disposition via incorporation in metal alloy waste forms

Lead Institution

Los Alamos National Laboratory

Principal Investigator

Christopher Taylor

Project type

Exploratory Research

The selection of an appropriate method for the disposition of long-lived radioisotopes resulting from fission processes in nuclear reactors is an exceptionally challenging problem. Particularly…

Characterization of zeolites

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Brian Riley

Project type

Limited Scope

We are using metal-exchanged zeolites as sorbents for methyl bromide under a DTRA project. This proposal is geared to allow us to characterize our zeolites using analytical instruments available at…

Computational Study of Membrane Protein Dynamics in Lipid Bilayers

Lead Institution

Bowling Green State University

Principal Investigator

H. Peter Lu

Project type

Exploratory Research

Membrane proteins are extremely important and complex in living cells. Studying the dynamical processes of membrane proteins is crucial for uncovering the fundamental mechanisms and dynamics…

X- Ray Diffraction Studies on alpha-Titanium and alpha-beta Titanium Alloys Developed by a Low Cost Novel Powder Metallurgy Process

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Vineet Joshi

Project type

Exploratory Research

Titanium and its alloys possess unique strength to weight advantages over other popular alloys mainly used for automobile applications. Use of these alloys could substantially reduce the automobile…

Interface and proximity effect in exchange biased epitaxial metallic hetero-nanostructures

Lead Institution

University of Washington

Principal Investigator

Kannan Krishnan

Project type

Limited Scope

The objective of this proposal is to address the interfacial and proximity effect as well as the structure-magnetism correlation in the epitaxial thin films and thin-film nanostructures. The…

Grating microfabrication for multimodal x-ray imaging

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Erin Miller

Project type

Exploratory Research

We propose to use the new microfabrication capabilities at EMSL to fabricate x-ray optics elements (gratings) for phase contrast x-ray imaging. Phase contrast x-ray imaging is a promising new…

Examination of Interfacial Chemical Interactions for Chemically Binding Nickel Catalysts to Porous Stabilized Zirconia Scaffolds

Lead Institution

Montana State University

Principal Investigator

Stephen Sofie

Project type

Limited Scope

Electrodes for electro-chemical energy conversion based on catalyst coatings offer substantial potential for creating more effective anode and cathode structures whilst yielding an opportunity to…

Analysis of Natural Aquifer Sediments to Characterize Potential Intercalation of TCE by Constituent Clay Minerals: A Rapid-Access Research Proposal Submitted to The Pacific Northwest National Laboratory

Lead Institution

University of Arizona

Principal Investigator

Mark Brusseau

Project type

Limited Scope

Pump-and-treat systems are widely used to remediate hazardous waste sites wherein groundwater is contaminated by compounds such as TCE (trichloroethene). It is well known that removal of…

A Microfabricated Preconcentration and Chemical Band Pass Filter for Volatile Organic Chemical Analysis

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Jon Wahl

Project type

Exploratory Research

The Department of Homeland Security Science and Technology Directorate has requested a solution to detect and alert the presence of WMD, explosives, humans, contraband, and anomalous substances in…

A Molecular Study of Electron/Hole Trapping in Irradiated Container Glass for Nuclear Forensics Investigations

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Jon Schwantes

Project type

Exploratory Research

Glass is well known for its resistance to damage from high radiation fields. Due to this resistive property, glass has been used as the storage matrix of choice for highly radioactive material, from…

EDRN Biomarker Reference and Resource Center with the Department of Energy

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Tao Liu

The purpose of the Early Detection Research Network (EDRN) Biomarker Reference and Resource Center (BRRC) is to develop a multiplex quantitative MS-based method, based on LC-SRM-MS for simultaneous…

Computational Study of Membrane Protein Dynamics in Lipid Bilayers

Lead Institution

Bowling Green State University

Principal Investigator

H. Peter Lu

Project type

Limited Scope

Membrane proteins are extremely important and complex in living cells. Studying the dynamical processes of membrane proteins is crucial for uncovering the fundamental mechanisms and dynamics…

Unveiling the structure, dynamics and spectral properties of aqueous clusters: A new theoretical approach

Lead Institution

University of California, Berkeley

Principal Investigator

Martin Head-Gordon

Project type

Exploratory Research

Elucidating the nature of aqueous solvation and in particular of hydrogen bonding are important for understanding chemical reactions in the atmosphere and at aqueous interfaces. Infrared (IR) and …

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