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Projects

As a scientific user facility, the Environmental Molecular Sciences Laboratory (EMSL) provides expertise, instrumentation, and resources to 250 projects each year. 

Projects displayed below reflect information and abstracts that were published before April 30, 2024. To review current EMSL user projects, visit Science Central™.

  • Projects beginning at or after given date.
    Projects ending at or before given date.

Molecular analysis of initiation factor complexes contain eIF3

Lead Institution
University of California, Davis
Principal Investigator
Suzanne Miyamoto
Project type
Large-Scale EMSL Research
The large multi-subunit eukaryotic initiation factor eIF3 is an essential component of translation initiation in all cells. In mammalian cells it is responsible for recruiting the eIF2-GTP-tRNA(i…

Study of the electronic properties of graphene-based materials

Lead Institution
CySilicoTech
Principal Investigator
Constantinos Zeinalipour
Project type
Exploratory Research
The aim of this proposal is to study the electronic structure of graphite, graphene and graphite intercalation compounds (GICs), in order to elucidate the origin of contrast in Scanning Tunneling…

Burkholderia Proteomoics

Lead Institution
University of Medicine and Dentistry, New Jersey Medical School
Principal Investigator
Steven Schutzer
Project type
Large-Scale EMSL Research
Burkholderia mallei, a biothreat agent, is the causative bacterial agent of glanders. Currently, there is no rapid discriminating diagnostic assay, no vaccine, and no reliable therapy. Gaps in our…

Growth-phase regulation of the proteome of Rhodobacter capsulatus.

Lead Institution
Memorial University of Newfoundland
Principal Investigator
Andrew Lang
Project type
Exploratory Research
The alpha-proteobacterium Rhodobacter capsulatus uses a histidyl-aspartyl signaling system for growth-phase-dependent regulation of expression of some genes. The response regulator protein CtrA is…

Growth of Single Crystal La2CuO(4+delta) films

Lead Institution
Argonne National Laboratory
Principal Investigator
Steve Heald
Project type
Exploratory Research
Recently La2CuO(4+delta) was found to undergo an interesting light-induced transient phase transition. We propose to use XAFS to look at the local structural changes occurring about the Cu and La…

Single Molecule Studies of Multi-Chromophoric Foldamers

Lead Institution
Washington State University
Principal Investigator
Alexander Li
Project type
Exploratory Research
Folding is a strategy ubiquitously used by nature to accomplish remarkable functions such as molecular recognition and enzymatic chemical catalysis. Since we are unable to design synthetic polymers…

Computer Simulation of Defects and Interfaces in Nuclear Fuel Materials

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Ram Devanathan
Project type
Exploratory Research
The objective of this proposal is to simulate the synergistic effects of radiation damage, elevated temperature and stress on microstructural evolution and fission gas bubble evolution in nuclear…

A proteomic perspective of biodiversity

Lead Institution
National Ecological Observatory Network
Principal Investigator
John Parnell
Project type
Exploratory Research
- The relationship between biodiversity and ecosystem stability has become a central focus for ecologists, particularly in the face of environmental stresses and global climate change. Although…

Material Interactions at Interfaces in Solid Oxide Fuel Cells

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
John Hardy
Project type
Exploratory Research
Solid oxide fuel cells (SOFCs) are multicomponent devices that operate at high temperatures (>700C) to efficiently convert chemical energy to electrical energy. Because the components of an SOFC…

Investigating Post-translational modifications of kinesin

Lead Institution
University of California, Irvine
Principal Investigator
Steven Gross
Project type
Exploratory Research
Molecular motor-based transport is essential for numerous cellular functions, and much of it is carried out by the molecular motor kinesin. Impaired or altered kinesin function is implicated in many…

Breast Cancer Biomarkers in Nipple Aspirate Fluid

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Richard Zangar
Project type
Exploratory Research
Breast cancer is responsible for ~43,000 deaths per year, a number which could be reduced dramatically by early detection of the disease. Currently, detection of breast cancer relies primarily on…

Microsampling Isotope Ratio Mass Spectrometer Development

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Helen Kreuzer
Project type
Exploratory Research
We are using a combination of laser ablation, catalytic reactor technology, and systems engineering to develop a novel device that converts the O and H in solid organic samples to CO and H2,…

Characterizing biofilm development of a bacterial biological control agent

Lead Institution
Oregon State University
Principal Investigator
Walter Mahaffee
Project type
Exploratory Research
There is increasing economic and political pressure for the implementation of sustainable practices for management of agro-ecosystems. The use of biocontrol agents to manage plant diseases has been…