Projects

As a scientific user facility, the Environmental Molecular Sciences Laboratory (EMSL) provides expertise, instrumentation, and resources to 250 projects each year.

EMSL projects displayed on the EMSL web site project page reflect project abstracts and information migrated to this page before April 30, 2024. To review current and past EMSL user projects, visit EMSL Science Central.™

Evaluation of type 1 diabetes biomarker candidates in plasma samples of the DAISY cohort

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Ernesto Nakayasu

Type 1 diabetes (T1D) is a devastating disease that reduce the life expectancy by over one decade. Its treatment is based solely on exogenous insulin administration and there is no cure or remission…

Fabrication and Characterization of Carbon Nanotube-based Composites

Lead Institution

University of California, San Diego

Principal Investigator

Sungho Jin

Project type

Exploratory Research

Recent years have witnessed the rapid progress in the fabrication of functional nanostructured materials. We have succeeded in making a variety of nanomaterials including nanoparticles, multiwalled…

Second Harmonic Generation from Organic Water/Air Interfaces

Lead Institution

University of Colorado

Principal Investigator

Alan Maccarone

Project type

Exploratory Research

Investigate the formation of organic radicals following ozonation of long chain hydrocarbons.

MICROBES PERSIST: SYSTEMS BIOLOGY OF THE SOIL MICROBIOME

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Ljiljana Pasa-Tolic

Soils store more carbon than the atmosphere and biosphere combined, yet the mechanisms that regulate soil C remain elusive. While plant roots are the initial source of carbon (C) that enters…

In situ X-Ray Computed Tomography for study of glass melter operation

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Steven Luksic

X-ray computed tomography (CT) analysis will support waste-glass research by analyzing room-temperature samples and adapting a furnace for use in the CT instrument. Developing a glass-melting furnace…

Non-covalent interactions of atmospherically and geologically important species

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Sotiris Xantheas

We will rely on the highly scalable (T) module of NWChem's CCSD(T) electronic structure method to derive accurate interaction potentials between C60 molecules. These will be used to obtain an ab…

Molecular Characterization of Dissolved Organic Matter from High Altitude Meadow Soils

Lead Institution

University of Wyoming

Principal Investigator

Mengqiang Zhu

Project type

Limited Scope

Floor-irrigated high-altitude meadows in the Rocky Mountains are important agroecosystems for hay production. However, the soil has a high nitrogen (N) fixation capability due to high C/N ratios,…

Assessing Organo-metal and Organo-Mineral controls on Soil Organic Matter stabilization in B horizons using a diverse set of A horizons

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Nancy Hess

Soil organic matter (SOM) is transformed by microbial processes and transported through soils by water. SOM leached from A horizons and can be stabilized through mineral-organic and metal-organic…

Characterization of Novel Biocompatible Carbon Nanomaterials

Lead Institution

University of Oregon

Principal Investigator

Benjamin McMorran

Carbon nanohoops ([n]cycloparaphenylenes or CPPs) are tunable building blocks with applications in fluorescence microscopy, nanotechnology, and electronics. The nanohoop units are biocompatible…

Transcription initiation in the context of chromatin

Lead Institution

University of California, Berkeley

Principal Investigator

Eva Nogales

The genetic information of eukaryotic cells is packaged into dense chromatin, which comes in the form of nucleosome arrays. Access to specific genomic sites requires that nucleosomes are remodeled to…

PNNL/Pfizer Project for the Development and Evaluation of Nanoproteomics Approaches

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Jon Jacobs

PNNL has developed and continues to develop multiple approaches and analytical capabilities for nanoproteomics; to process and analyze via liquid chromatography mass spectrometry (LC-MS) samples on…

Are Calcite Nanoparticles or Organics Causing Autofluorescence of Microbially Produced Calcium Carbonate Precipitates?

Lead Institution

Montana State University

Principal Investigator

Robin Gerlach

Project type

Limited Scope

Microbially induced mineralization is a broad field of research that investigates the precipitation of minerals induced by the presence or activity of microorganisms. Specifically, Microbially…

Structure of the TRAMP RNA surveillance complex

Lead Institution

Utah State University

Principal Investigator

Sean Johnson

This proposal seeks access to the PNCC cryo-EM facility in order to obtain structural information for the TRAMP (Trf4-Air2-Mtr4 polyadenylation) complex. The goal is to better understand assembly of…

Determining Protein Interactions Involving Essential Genes of Unknown Function

Lead Institution

University of Delaware

Principal Investigator

Mark Blenner

Project type

Exploratory Research

The DOE's goal of advancing biological and environmental research for the development of renewable and sustainable sources of biofuels and bio-based chemicals from biomass relies on our ability…

Fundamental Structure-Property Relationships Governing the Electrochemical Activity of Epitaxial Heterostructures

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Scott Chambers

Complex oxides have the widest range of properties of any class of materials explored to date. However, with many degrees of freedom come many possible outcomes. Consequently, controlled synthesis of…

Structural investigation of transcription reprogramming by E. coli stringent starvation protein A

Lead Institution

Duke University

Principal Investigator

Maria Schumacher

Stringent starvation protein A (SspA) is a global transcriptional regulator that associates with RNA polymerase (RNAP) and plays roles in the activation of the stringent response and pathogenesis in…

Protemic Analysis of Naturally Ocurring Methane Oxidizing Archaeal Communities

Lead Institution

Massachusetts Institute of Technology

Principal Investigator

Edward DeLong

Project type

Exploratory Research

Microbial mediated anaerobic methane oxidation (AOM) in marine sediments represents a significant but poorly understood carbon sink throughout the world's oceans. Mounting geochemical and…

MKP1 regulates plant metabolite signals that induce bacterial virulence: How and where are these signals controlled?

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Thomas Metz

PNNL will perform both untargeted and targeted metabolomics analyses of plant exudate and tissue samples to assess mechanisms of altered resistance in MKP1

Ion-beam-induced damage mechanisms in thin film oxides

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Steven Spurgeon

This project aims to investigate defects induced by ion-beam irradiation in functional oxide systems. Ion-beam irradiation of materials leads to the creation of a range of defects, including Frenkel…

The composition, transport, and fate of soil organic matter and pyrogenic carbon after prescribed burning

Lead Institution

University of Georgia

Principal Investigator

Rebecca Abney

Project type

Exploratory Research

Prescribed burning has exponentially increased in the United States over the past five years due to growing research into its use for land management and recent changes in legislation. While the…

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