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Functional and Systems Biology

The Functional and Systems Biology Area focuses on elucidating and harnessing the biochemical pathways that connect gene functions to complex phenotypic responses through a deep understanding of interactions within cells, among cells in communities, and between cellular membrane surfaces and their environment for microbes (archaea, bacteria, algae), fungi, and plants. This understanding will encompass experimental observations, metabolic reconstruction and modeling, leading to improved strategies for designing plants, fungi, and microbes for biofuels and bio-based products, as well as unraveling the complexities of carbon, nutrient, and elemental cycles within cells and their immediate environment.

Structural Biology

Structural Biology
All living systems rely on the tiniest of cellular functions to maintain health and vigor. When these functions break from disease or other stresses, the whole organism suffers. Structural biology…

Biomolecular Pathways

Biomolecular Pathways
Essential biological molecules—like proteins, lipids, RNA, and metabolites—create the language of gene expression and energy exchange that leads to healthy cells, organisms, and living systems. EMSL…

Cell Signaling and Communications

Cell Signaling and Communications
Billions of cells, each with a one-of-a-kind role and behavior, make up living systems. Our expertise in systems biology, functional genomics, and biochemistry, enhanced by state-of-the-art…

10-Year Objective

Digital Phenome

illustration of soil and organisms
DigiPhen is a platform for data production and data–model integration across the fields of structural biology, biomolecular pathways, and cellular signaling and communication that connects the molecular basis of function to observable or desirable phenotypes.
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