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Instruments & Resources

The Environmental Molecular Sciences Laboratory (EMSL) is home to the user facility’s 150 instruments that can be leveraged for biological, environmental, and computing research needs. The instruments and resources are available to researchers who are awarded funding through EMSL’s open call for proposals. The categories below reflect instrument groups for specific research areas. When selected, the instrument group is filtered by the instruments that fall under that category. By reviewing the instrument pages, researchers can learn how the instrumentation can be applied to research. The instrument and resource pages can also be used to identify the instrument owners and Integrated Research Platform area leads to follow up with questions before submitting an abstract to a call for proposal.

Atom Probe Tomography

Atom proble tomography is a material analysis technique available at the Environmental Molecular Sciences Laboratory (EMSL) through the EMSL User Program.
Related Instrument Groups
Chemical Imaging
Structural Tomography & Topography

Mass Spectrometry Imaging

The Environmental Molecular Sciences Laboratory's mass spectrometry capabilities allow researchers to investigate the spatial distribution of molecules within biological samples. Mass spectrometry imaging resources are available to researchers who submit proposals and are awarded funding through the EMSL User Program.
Related Instrument Groups
Chemical Imaging
Omics & Organic Matter Analysis

Super resolution structured illumination and Airyscan fluorescence microscope

The Airyscan module, mounted on the confocal fluorescence microscope, provides 3D imaging with a superior detection sensitivity and speed compared when compared to the standalone structured illumination microscopy system or classic confocal microscope. This capability is available at the Environmental Molecule Sciences Laboratory (EMSL) through the EMSL User Program.
Related Instrument Groups
Optical Imaging

Coherent Anti-Stokes Raman Scattering and Stimulated Raman

Inverted scanning confocal microscope equipped for chemical and biological imaging. Label-based, label-free, and time-resolved imaging of cellular and subcellular dynamics possible in biosystems…
Related Instrument Groups
Chemical Imaging

Electron Paramagnetic Resonance

The Environmental Molecular Sciences Laboratory (EMSL) offers electron paramagnetic resonance spectroscopy capabilities through the EMSL User Program.
Related Instrument Groups
NMR & EPR

Lattice Light Sheet

The Lattice Light Sheet microscope is a tool for imaging living organisms or cells with up to single molecule resolution. This resource is available at the Environmental Molecular Sciences Laboratory (EMSL), a Department of Energy user facility.
Related Instrument Groups
Optical Imaging

Liquid State NMR for Metabolomics

The Environmental Molecular Sciences Laboratory (EMSL) offers liquid state nuclear magnetic resonance capabilities for metabolomics research through the EMSL User Program.
Related Instrument Groups
NMR & EPR
Omics & Organic Matter Analysis

Liquid State NMR for Structural Biology

Liquid state nuclear magnetic resonance at the Environmental Molecular Sciences Laboratory can be used to investigate nucleic acids, peptides, and heterogeneous cell-wall biopolymers, such as lignin and oligosaccharides.
Related Instrument Groups
NMR & EPR

Nanoscale Fourier Transform Infrared Spectroscopy

Nanoscale Fourier transform infrared spectroscopy (nano-FTIR) is a high-resolution chemical imaging system, which combines the nanoscale spatial resolution of atomic force microscopy with the…
Related Instrument Groups
Chemical Imaging
Structural Tomography & Topography

Nanoscale Secondary Ion Mass Spectrometry

The Environmental Molecular Sciences Laboratory (EMSL) offers the nanoscale secondary ion mass spectrometry (NanoSIMS) capability through the EMSL User Program's open calls for proposals.
Related Instrument Groups
Chemical Imaging

Solid State NMR

The Environmental Molecular Sciences Laboratory (EMSL) has five solid state nuclear magnetic spectrometers that utilize high-field superconducting magnets.
Related Instrument Groups
NMR & EPR

Raman Atomic Force Microscopy

The Environmental Molecular Sciences Laboratory's Raman atomic force microscopy resources are available to the scientific community through open calls for proposals.
Related Instrument Groups
Chemical Imaging
Structural Tomography & Topography

Time-of-Flight Secondary Ion Mass Spectrometry

Time-of-flight (ToF) secondary ion mass spectrometry (SIMS) is available at the Environmental Molecular Sciences Laboratory through open calls for proposals.
Related Instrument Groups
Chemical Imaging

X-ray Photoelectron Spectroscopy

Researchers can access X-ray photoelectron spectroscopy at the Environmental Molecular Sciences Laboratory (EMSL) to provide information on the chemical nature and state of detected elements. This resource is available through the EMSL User Program.
Related Instrument Groups
Chemical Imaging

NanoLive

The NanoLive 3D Cell Explorer CX-A is a microscopy platform available through the EMSL User Program. This platform is designed for repeat observations over time on bacterial and eukaryotic cells.
Related Instrument Groups
Optical Imaging