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Sankar Krishnamoorthy
Chemist

Sankar Krishnamoorthy is chemist with the Cell Signaling and Communications Integrated Research Platform. He has more than 11 years of experience in organic chemistry through the development of new synthetic methods and a variety of tailored small molecules to tackle challenges in medicinal chemistry, biomedical device development, organic flow batteries, and chemical biology. Krishnamoorthy has experience in organic redox flow batteries, surface functionalization of 3-D printed materials,metal oxides with small molecules, synthetic and bio polymers (DNA).

He is contributing to EMSL's chemical biology capability development. Krishnamoorthy is engaging EMSL users for probe development to understand enzyme functions and biochemical pathway characterization in BER relevant biosystems.

Research Interests

  • Chemical biology
  • Small molecule probes
  • Biomolecule conjugations
  • Organic chemistry
  • Organic reaction methods
  • Functional polymers

Education

  • Ph.D. in Chemistry, University of Southern California – 2017
  • M. Sc. In Chemistry, Indian Institute of Technology Guwahati – 2009
  • B. Sc. in Chemistry, University of Madras – 2007

Awards and Recognition

  • The William P. Weber Award for mentoring, service and outstanding graduate research in organic and preparative chemistry, USC, 2017                                      
  • Excellence in graduate student research award, USC, 2012                                                                          
  • Outstanding performance award (Bronze level), GSK, 2010

Affiliations and Professional Service

  • Post-Doctoral Research associate – PNNL (Dr. Aaron T. Wright)
  • Post-Doctoral Scholar – California Institute of Technology (Prof. Robert H. Grubbs)
  • Member – American Chemical Society
  • Industrial Placement Student Researcher GlaxoSmithKline R&D (UK)                                                                 

Patents

  • Inexpensive Metal-free Organic Redox Flow Battery (ORBAT) for Grid-scale Storage. Narayanan, S.R; Prakash, G.K.S; Yang, B; Burkhardt, H.L; Krishnamoorthy, S. US patent 9,614,245.
  • Materials for high-performance aqueous organic redox flow batteries. Narayanan, S.R; Prakash, G.K.S; Aniszfeld, R; Yang, B; Burkhardt, H.L; Krishnamoorthy, S. Murali, A; Nirmalchander, A. US patent 10833345.

Publications

2022

An activity-based probe targeting the streptococcal virulence factor C5a peptidase, Krishnamoorthy, S; Steiger, A. K; Egbert, R. G; Wright, A. T.  Chem. Commun., 2022. 10.1039/d2cc01517j

2020

Aldehyde Functionalized Magnetic Particles to Capture Off-target Chemotherapeutic Agents. Krishnamoorthy, S; Grubbs, R. H. ACS Omega, 2020, 5, 45, 29121.

2019

Synthetic Advances in Nucleophilic and Related Tri- and Difluoromethylation Protocols. Munoz, S. B; Krishnamoorthy, S; Mathew, T; Prakash, G. K. S. Frontiers of Organofluorine Chemistry, 2019.

Next Generation Aqueous Flow Battery Chemistries. Narayanan, S.; Nirmalchandar, A; Murali, A; Yang, B; Hoober-Burkhardt, L; Krishnamoorthy, S; Prakash, G.K.S. Current opinion in Electrochemistry. 2019, 18, 72-80.

2018

Understanding and Mitigating Capacity Fade in Aqueous Organic Redox Flow Batteries. Murali, A; Nirmalchandar, A; Krishnamoorthy, S; Hoober-Burkhardt, L; Yang, B; Soloveichik, G; Prakash, G.K; Narayanan, S. J. Electrochem. Soc. 2018, 165, A1193-A1203.

Nucleophilic Difluoromethylation of Aromatic Aldehydes Using Trimethyl(trifluoromethyl)silane (TMSCF3). Krishnamoorthy, S; Kar, S; Kothandaraman, J; Prakash, G.K.S. J. Fluor. Chem., 2018, 208, 10.

2017

Crystal Chemistry of Iron Muscovite Clay: an Earth-Abundant and Sustainable Material for Electrochemical Applications. Zhou, S; Howard, E; Liu, J; Nolan, K; Krishnamoorthy, S; Rangel, G; Sougrati, M; Prakash, G. K. S; Page, K; Melot, B. ACS Appl. Mater. Interfaces, 2017, 9, 34024.

Trifluoromethyl Ether and Trifluoromethyl Thioether Synthesis by Silver Catalyzed Decarboxylative Fluorination. Krishnamoorthy, S; Schnell, S.D; Dang, H; Prakash, G.K.S. J. Fluor. Chem., 2017, 203, 130.

A New Michael-Reaction-Resistant Benzoquinone for Aqueous Organic Redox Flow Battery. Hoober-Burkhardt, L; Krishnamoorthy, S; Yang, B; Murali, A; Nirmalchandar, A; Prakash, G.K.S; Narayanan, S.  J. Electrochem. Soc. 2017, 164, A1-A8. 

Trifluoromethyl Ether and Trifluoromethyl Thioether Synthesis by Silver Catalyzed Decarboxylative Fluorination. Krishnamoorthy, S; Schnell, S.D; Dang, H; Prakash, G.K.S. J. Fluor. Chem., 2017, 203, 130.

A New Michael-Reaction-Resistant Benzoquinone for Aqueous Organic Redox Flow Battery. Hoober-Burkhardt, L; Krishnamoorthy, S; Yang, B; Murali, A; Nirmalchandar, A; Prakash, G.K.S; Narayanan, S.  J. Electrochem. Soc. 2017, 164, A1-A8. 

Silicon-based Reagents for Difluoromethylation and Difluoromethylenation Reactions. Krishnamoorthy, S; Prakash, G.K.S. Synthesis, 2017, 49, 3394.

2016

Direct Difluoromethylenation of Carbonyl Compounds by Using TMSCF3: The Right Conditions. Krishnamoorthy, S; Kothandaraman, J; Saldana, J; Prakash, G.K.S. Eur. J. Org. Chem. 2016, 4965.

High-Performance Aqueous Organic Flow Battery with Quinone-Based Redox Couples at Both Electrodes. Yang, B; Hoober-Burkhardt, L; Krishnamoorthy, S; Prakash, G.K.S; Narayan, S., J. Electrochem. Soc. 2016, 163, A1442. 

2015

Direct S-Difluoromethylation of Thiols Using the Ruppert-Prakash Reagent. Prakash, G.K.S; Krishnamoorthy, S; Kar, S; Olah, G.A. J. Fluor. Chem., 2015, 180, 186.

Tributyl(difluoromethyl)stannane. Prakash, G.K.S; Krishnamoorthy, S; Ganesh, S.K. e-Eros Encycl. Reagents Org. Synth. 2015, DOI: 10.1002/047084289X.rn01771.

2014

N-Difluoromethylation of Imidazole and Benzimidazole Using the Ruppert-Prakash Reagent. Prakash, G.K.S.; Krishnamoorthy, S; Ganesh, S.K; Kulkarni, A; Haiges, R; Olah, G.A. Org. Lett. 2014, 16, 54.

2013

Reusable Cu2O-Nanoparticle-Catalyzed Amidation of Aryl Iodides. Jammi, S; Krishnamoorthy, S; Saha, P; Kundu, D.S; Sakthivel, S; Ali, M.A; Paul, R; Punniyamurthy, T. Synlett, 2009, 3323.