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Andrey Liyu
Engineer III

Andrey Liyu is an engineer with the Environmental Molecular Sciences Laboratory (EMSL)'s Instrument Development and Automation Laboratory. Primarily, he develops novel laboratory automation systems supporting EMSL and Pacific Northwest National Laboratory (PNNL) research. Currently, he is developing data acquisition and controls systems for Rutherford backscatter detectors and associated ion accelerator, Mössbauer detectors, nuclear magnetic resonance devices, and different types of spectrometers and mass-spectrometers.

In the late 1980s, Liyu began his career as a software engineer at the 600 MeV Proton Accelerator of Moscow, Meson Factory, Russia (1987 – 2003). In 1999, he worked for the European Organization for Nuclear Research in Switzerland. Before coming to PNNL, he worked with accelerators at the Spallation Neutron Source within Oak Ridge National Laboratory (2003 – 2007). During his accelerator career, he developed control systems to automate various beam diagnostic instruments. Liyu also has expertise in distributed and real-time control systems.

Research Interests

Liyu’s research interests include developing data acquisition and controls systems for scientific instruments, such as real-time and distributed control systems. He creates novel control systems from hardware to user interface.

Education

  • MS in Electrical Engineering, Moscow State Technical University, 1987
  • MS in Computer Science, Moscow State Technical University, 1987

Patents

  • N. Browning, L. Kovarik, A.V. Liyu, A.J. Stevens. “Sparse sampling methods and probe systems for analytical instruments.” US Patent 10,431,419
  • N. Browning, L. Kovarik, A.V. Liyu, A.J. Stevens. “Optimized sub-sampling in an electron microscope.” US Patent 10,256,072
  • N. Browning, L. Carin, L. Kovarik, A.V. Liyu, A.J. Stevens, X. Yuan. “Compressive transmission microscopy.” US Patent 10,224,175
  • J. Laskin, A.V. Liyu, S.N. Nguyen. “Techniques for controlling distance between a sample and sample probe which such probe liberates analyte from a sample region for analysis with a mass spectrometer.” US Patent 10,134,572
  • Y. Ibraham, A.V. Liyu, R.J. Moore, D.J. Orton, S.M. Williams, Y. Zhu. “Method for direct delivering trace samples from small-size wells to liquid chromatography and mass spectrometry.” Provisional Patent Master ID 10055
  • A.J. Liyu, E.W. Robinson, N. Tolic. “Alignment Algorithm for Improved Formula Assignment of Complex High-Resolution Mass Spectra.” Provisional Patent Master ID 9805
  • Gehm, Michael; Hao,Weituo; Kovarik,Libor; Liyu,Andrey V; Luzi,Lorenzo; Stevens,Andrew J; Yang, Hao. “Analytical instruments and multi-dimensional analysis.” Provisional Patent Master ID 9343
  • Browning,Nigel; Kovarik,Libor; Liyu,Andrey V; Mehdi,Beata; Stevens,Andrew J. “Advanced analytical instruments and computational imaging. Provisional Patent Master ID 9371
  • Browning,Nigel; Kovarik,Libor; Liyu,Andrey V; Stevens,Andrew J. “Accurate Sparse Sampling for Low-Dose STEM Imaging Using Only the Microscope Scan Coils.” Provisional Patent Master ID 9149
  • Laskin,Julia; Liyu,Andrey V; Nguyen,Son N.” Techniques for controlling distance between a sample and sample probe instrumentation which such instrumentation liberates analyte ions from a sample region and directs these ions to a mass spectrometer for analysis.” Provisional Patent Master ID 8981
  • Browning,Nigel; Carin, Lawrence; Kovarik,Libor; Liyu,Andrey V; Stevens,Andrew J; Yuan, Xin. “Compressive transmission electron microscopy.” Provisional Patent Master ID 8925
  • Browning,Nigel; Carin, Lawrence; Kovarik,Libor; Liyu,Andrey V; Stevens,Andrew J; Yuan, Xin. “Compressive transmission electron microscopy.” Provisional Patent Master ID 8904
  • Heath,Brandi S; Lanekoff,Ingela T; Laskin,Julia; Liyu,Andrey V. “Automated system for chemical imaging using nanospray desorption electrospray ionization mass spectrometry.”  Provisional Patent Master ID 8261

Publications

2020

Williams S.M., A.V. Liyu, C. Tsai, R.J. Moore, D.J. Orton, W.B. Chrisler, and M.J. Gaffrey, et al. 2020. "Automated coupling of nanodroplet sample preparation with liquid chromatography-mass spectrometry for high-throughput single-cell proteomics." Analytical Chemistry 92, no. 15:10588-10596. PNNL-SA-152553. doi:10.1021/acs.analchem.0c01551

2019

Dou M., C.D. Chouinard, Y. Zhu, G. Nagy, A.V. Liyu, Y.M. Ibrahim, and R.D. Smith, et al. 2019. "Nanowell-mediated multidimensional separations combining nanoLC with SLIM IM-MS for rapid, high-peak-capacity proteomic analyses." Analytical and Bioanalytical Chemistry 411, no. 21:5363-5372. PNNL-SA-146403. doi:10.1007/s00216-018-1452-5

Mehdi B.L., A. Stevens, L. Kovarik, N. Jiang, H.S. Mehta, A.V. Liyu, and S.M. Reehl, et al. 2019. "Controlling the Spatio-Temporal Dose Distribution During STEM Imaging by Subsampled Acquisition: In-Situ Observations of Kinetic Processes in Liquids." Applied Physics Letters 115, no. 6:Article Number 063102. PNNL-SA-145156. doi:10.1063/1.5096595

Stopka S.A., L.Z. Samarah, J.B. Shaw, A.V. Liyu, D. Velickovic, B.J. Agtuca, and C. Kukolj, et al. 2019. "Ambient Metabolic Profiling and Imaging of Biological Samples with Ultrahigh Molecular Resolution using Laser Ablation Electrospray Ionization 21 Tesla FTICR Mass Spectrometry." Analytical Chemistry 91, no. 8:5028-5035. PNNL-SA-137600. doi:10.1021/acs.analchem.8b05084

2018

Stevens A.J., L. Luzi, H. Yang, L. Kovarik, B.L. Mehdi, A.V. Liyu, and M. Gehm, et al. 2018. "A Sub-Sampled Approach to Extremely Low-Dose STEM." Applied Physics Letters 112, no. 4:Article No. 043104. PNNL-SA-126577. doi:10.1063/1.5016192

2017

Nguyen S.N., A.V. Liyu, R.K. Chu, C.R. Anderton, and J. Laskin. 2017. "Constant-Distance Mode Nanospray Desorption Electrospray Ionization Mass Spectrometry Imaging of Biological Samples of Complex Topography." Analytical Chemistry 89, no. 2:1131-1137. PNNL-SA-119825. doi:10.1021/acs.analchem.6b03293

Tolic N., Y. Liu, A.V. Liyu, Y. Shen, M.M. Tfaily, E.B. Kujawinski, and K. Longnecker, et al. 2017. "Formularity: Software for Automated Formula Assignment of Natural and Other Organic Matter from Ultra-High Resolution Mass Spectra." Analytical Chemistry 89, no. 23:12659-12665. PNNL-SA-128094. doi:10.1021/acs.analchem.7b03318

2016

Kovarik, L., A. Stevens, A. Liyu, and N. D. Browning. 2016. “Implementing an Accurate and Rapid Sparse Sampling Approach for Low-Dose Atomic Resolution STEM Imaging.” Applied Physics Letters 109 (16). https://doi.org/10.1063/1.4965720.

2015

Colby R.J., D.H. Alsem, A.V. Liyu, and B.C. Kabius. 2015. "A method for measuring the local gas pressure within a gas-flow stage in situ in the transmission electron microscope." Ultramicroscopy 153. PNNL-SA-100727. doi:10.1016/j.ultramic.2015.01.002

2014

Du Y., T.C. Droubay, A.V. Liyu, G. Li, and S.A. Chambers. 2014. "Self-corrected Sensors Based On Atomic Absorption Spectroscopy For Atom Flux Measurements In Molecular Beam Epitaxy." Applied Physics Letters 104, no. 16:Article No. 163110. PNNL-SA-101564. doi:10.1063/1.4873544

Xue J., N.G. Isern, R. Ewing, A.V. Liyu, J.A. Sears, H. Knapp, and J. Iversen, et al. 2014. "New generation NMR bioreactor coupled with high-resolution NMR spectroscopy leads to novel discoveries in Moorella thermoaceticum metabolic profiles." Applied Microbiology and Biotechnology 98, no. 19:8367-8375. PNNL-SA-96892. doi:10.1007/s00253-014-5847-8

2012

Lanekoff I.T., B.S. Heath, A.V. Liyu, M. Thomas, J.P. Carson, and J. Laskin. 2012. "An Automated Platform for High-Resolution Tissue Imaging Using Nanospray Desorption Electrospray Ionization Mass Spectrometry." Analytical Chemistry 84, no. 19:8351-8356. PNNL-SA-89054.

2010

Shah A.R., N. Jaitly, N. Zuljevic, M.E. Monroe, A.V. Liyu, A.D. Polpitiya, and J.N. Adkins, et al. 2010. "An architecture for real time data acquisition and online signal processing for high throughput tandem mass spectrometry." In 5th IEEE International Conference on e-Science, 88 - 93. Piscataway, New Jersey:IEEE. PNNL-SA-67849. doi:10.1109/e-Science.2009.21

2008

Belov M.E., B.H. Clowers, D.C. Prior, W.F. Danielson, A.V. Liyu, B.O. Petritis, and R.D. Smith. 2008. "Dynamically Multiplexed Ion Mobility Time-of-Flight Mass Spectrometry." Analytical Chemistry 80, no. 15:5873-5883. PNNL-SA-59401. doi:10.1021/ac8003665

Ibrahim Y.M., M.E. Belov, A.V. Liyu, and R.D. Smith. 2008. "Automated Gain Control Ion Funnel Trap for Orthogonal Time-of-Flight Mass Spectrometry." Analytical Chemistry 80, no. 14:5367-5376. PNNL-SA-59266. doi:10.1021/ac8003488